Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. - Wikidata - awgldk - TriplyDB

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.

http://www.wikidata.org/entity/Q44373729

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The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130)BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway Cysteine-based regulation of the CUL3 adaptor protein Keap1 The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention The Role of Cyclo(His-Pro) in Neurodegeneration Overview of Nrf2 as Therapeutic Target in Epilepsy Mitochondrial quality control: decommissioning power plants in neurodegenerative diseases Roles nrf2 plays in myeloid cells and related disorders Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response A blueberry-enriched diet improves renal function and reduces oxidative stress in metabolic syndrome animals: potential mechanism of TLR4-MAPK signaling pathway Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes.NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector Crystal structure of quinone reductase 2 in complex with resveratrol Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis Reactive oxygen species in inflammation and tissue injury Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Mechanism of chemical activation of Nrf2 A novel acylaminoimidazole derivative, WN1316, alleviates disease progression via suppression of glial inflammation in ALS mouse model Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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P2860

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.

http://www.wikidata.org/entity/Q44373729

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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name

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@en

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@nl

type

label

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@en

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@nl

prefLabel

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@en

Keap1 regulates both cytoplasm ...... in response to electrophiles.

@nl

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J.1365-2443.2003.00640.X

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Keap1 regulates both cytoplasm ...... in response to electrophiles.

@en

P2093

Ken Itoh

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Nobunao Wakabayashi

http://www.w3.org/2001/XMLSchema#string

Tania O'Connor

http://www.w3.org/2001/XMLSchema#string

Tetsuro Ishii

http://www.w3.org/2001/XMLSchema#string

Yasutake Katoh

http://www.w3.org/2001/XMLSchema#string

P2860

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

Ubiquitin-dependent protein degradation

Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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