Werner syndrome protein contains three structure-specific DNA binding domains. - Wikidata - awgldk - TriplyDB

Werner syndrome protein contains three structure-specific DNA binding domains.

Werner syndrome protein contains three structure-specific DNA binding domains.

http://www.wikidata.org/entity/Q44611028

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Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1 The spectrum of WRN mutations in Werner syndrome patients Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes Coupling DNA-binding and ATP hydrolysis in Escherichia coli RecQ: role of a highly conserved aromatic-rich sequence The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase Crystal structure of the HRDC domain of human Werner syndrome protein, WRN Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.Acetylation regulates WRN catalytic activities and affects base excision DNA repair.Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3 DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2 Delineation of WRN helicase function with EXO1 in the replicational stress response Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.G-quadruplex nucleic acids and human disease The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein.Junction of RecQ helicase biochemistry and human disease.Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.Roles of the Werner syndrome RecQ helicase in DNA replication.A role for WRN in telomere-based DNA damage responses.Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.Structure-specific DNA binding and bipolar helicase activities of PcrA.Genetic studies of human DNA repair proteins using yeast as a model system.Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.Structure and function of RecQ DNA helicases.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease Human RecQ helicases in DNA repair, recombination, and replication.

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P2860

Werner syndrome protein contains three structure-specific DNA binding domains.

http://www.wikidata.org/entity/Q44611028

description

2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

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2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Werner syndrome protein contains three structure-specific DNA binding domains.

@en

Werner syndrome protein contains three structure-specific DNA binding domains.

@nl

type

label

Werner syndrome protein contains three structure-specific DNA binding domains.

@en

Werner syndrome protein contains three structure-specific DNA binding domains.

@nl

prefLabel

Werner syndrome protein contains three structure-specific DNA binding domains.

@en

Werner syndrome protein contains three structure-specific DNA binding domains.

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Werner syndrome protein contains three structure-specific DNA binding domains.

@en

P2093

Bryan K Czyzewski

http://www.w3.org/2001/XMLSchema#string

Cayetano von Kobbe

http://www.w3.org/2001/XMLSchema#string

Nicolas H Thomä

http://www.w3.org/2001/XMLSchema#string

Nikola P Pavletich

http://www.w3.org/2001/XMLSchema#string

Vilhelm A Bohr

http://www.w3.org/2001/XMLSchema#string

P2860

Functional and physical interaction between WRN helicase and human replication protein A

Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

The Werner syndrome protein is a DNA helicase

Asymmetry of DNA replication fork progression in Werner's syndrome

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

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52997-53006

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scholarly article

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10.1074/JBC.M308338200

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52

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278

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2003-10-08T00:00:00Z

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P698

14534320

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P921

protein structure