The twisted ion-permeation pathway of a resting voltage-sensing domain.
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Water wires in atomistic models of the Hv1 proton channelVoltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domainsPortability of paddle motif function and pharmacology in voltage sensorsVoltage-gated proton channels: what's next?TRPM3 in temperature sensing and beyondVoltage gated ion channel function: gating, conduction, and the role of water and protonsStructure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channelChannelopathies of skeletal muscle excitabilityProton currents constrain structural models of voltage sensor activation.Mapping the membrane-aqueous border for the voltage-sensing domain of a potassium channel.The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor.Hydrophobic plug functions as a gate in voltage-gated proton channels.S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channels.A naturally occurring omega current in a Kv3 family potassium channel from a platyhelminthNon-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.Voltage-dependent gating in a "voltage sensor-less" ion channel.Sequential formation of ion pairs during activation of a sodium channel voltage sensorMutations in KCND3 cause spinocerebellar ataxia type 22.Calculation of the gating charge for the Kv1.2 voltage-activated potassium channelDown-state model of the voltage-sensing domain of a potassium channel.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutationsIon channel voltage sensors: structure, function, and pathophysiology.In search of a consensus model of the resting state of a voltage-sensing domainGenetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element.Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.Role of the outer pore domain in transient receptor potential vanilloid 1 dynamic permeability to large cationsFunctional extension of amino acid triads from the fourth transmembrane segment (S4) into its external linker in Shaker K(+) channels.The pore of the voltage-gated proton channelStructural basis for gating charge movement in the voltage sensor of a sodium channelMolecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains.Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel.Voltage Sensing in Membranes: From Macroscopic Currents to Molecular MotionsMolecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation.Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environmentCoupling between the voltage-sensing and pore domains in a voltage-gated potassium channel.Autonomous transmembrane segment S4 of the voltage sensor domain partitions into the lipid membraneObservation of σ-pore currents in mutant hKv1.2_V370C potassium channelsbSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles.Atomic constraints between the voltage sensor and the pore domain in a voltage-gated K+ channel of known structure
P2860
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P2860
The twisted ion-permeation pathway of a resting voltage-sensing domain.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@en
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@nl
type
label
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@en
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@nl
prefLabel
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@en
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@nl
P2093
P2860
P356
P1433
P1476
The twisted ion-permeation pathway of a resting voltage-sensing domain.
@en
P2093
Ehud Y Isacoff
Francesco Tombola
Medha M Pathak
P2860
P2888
P304
P356
10.1038/NATURE05396
P407
P577
2006-12-24T00:00:00Z
P5875
P6179
1036103016