Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
about
Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectinMechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptorModulatory roles for integrin activation and the synergy site of fibronectin during matrix assemblyPlatelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responsesSimulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands.The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cellsCharacterizing the microenvironment surrounding protein sites.The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis.Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAKRegulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3Heparin modulates the conformation and signaling of platelet integrin αIIbβ3Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain.Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and managementAntibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin.Recreation of the terminal events in physiological integrin activation.Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.Antibody response to fibronectin-binding adhesin FnbpA in patients with Staphylococcus aureus infections.Acidic extracellular pH promotes activation of integrin α(v)β(3).The final steps of integrin activation: the end gameDemystified...adhesion molecule deficiencies.Rising like the phoenix?Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismStabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand.A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins.Reconstruction of integrin activation.Bound fibrinogen distribution on stimulated platelets. Examination by confocal scanning laser microscopyMapping early conformational changes in alphaIIb and beta3 during biogenesis reveals a potential mechanism for alphaIIbbeta3 adopting its bent conformation.A genetic analysis of integrin function: Glanzmann thrombasthenia in vitroPerturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis.A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogenDistinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.Affinity modulation of integrin alpha 5 beta 1: regulation of the functional response by soluble fibronectin.Structure/function analysis of the integrin beta 1 subunit by epitope mapping.Integrin cytoplasmic domains mediate inside-out signal transduction.Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3.Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst.Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction.Calcium indirectly regulates immunochemical reactivity and functional activities of the N-domain of thrombospondin-1.Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation
P2860
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P2860
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh-hant
name
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@en
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@nl
type
label
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@en
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@nl
prefLabel
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@en
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@nl
P2093
P1476
Monoclonal antibodies to ligan ...... ty, specificity, and function.
@en
P2093
Frelinger AL 3rd
Ginsberg MH
P304
17106-17111
P407
P577
1991-09-01T00:00:00Z