Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus. - Wikidata - awgldk - TriplyDB

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

http://www.wikidata.org/entity/Q46140095

about

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.Clinical therapeutics in pregnancy.UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis Paracetamol pharmacokinetics and metabolism in young women.Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.Hormones, seizures, and lamotrigine: Oh, my!Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency.Alterations in drug disposition during pregnancy: implications for drug therapy.Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention.Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice.UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors.Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential.UDP-glucuronosyltransferases (UGTs) in neuro-olfactory tissues: expression, regulation, and function.Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions.Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia.Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes.Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10 Induction of mouse UDP-glucuronosyltransferase mRNA expression in liver and intestine by activators of aryl-hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor alpha, and nuclear fa Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.

P2860

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P2860

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

http://www.wikidata.org/entity/Q46140095

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

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2005年學術文章

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2005年學術文章

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name

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@en

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@nl

type

label

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@en

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@nl

prefLabel

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@en

Tissue-specific, inducible, an ...... syltransferase-1 (UGT1) locus.

@nl

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P1433

Journal of Biological Chemistry

P1476

Tissue-specific, inducible, an ...... osyltransferase-1 (UGT1) locus

@en

P2093

Deirdre Beaton

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Erin Brace-Sinnokrak

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Jocelyn Trottier

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Joseph K Ritter

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Kathy Senekeo-Effenberger

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Nghia Nguyen

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Olivier Barbier

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Robert H Tukey

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Rory P Remmel

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Shujuan Chen

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P2860

UDP-Glucuronosyltransferases

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues

Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity

Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

P304

37547-37557

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scholarly article

P356

10.1074/JBC.M506683200

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45

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P478

280

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Upendra A Argikar

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2005-09-09T00:00:00Z

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16155002

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