Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.
about
Electrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsNovel Zn2+-binding Sites in Human Transthyretin: IMPLICATIONS FOR AMYLOIDOGENESIS AND RETINOL-BINDING PROTEIN RECOGNITIONPhenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative StressMinding metals: tailoring multifunctional chelating agents for neurodegenerative disease.A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.Oxidative condensations to form benzimidazole-substituted potassium organotrifluoroborates.Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseDesign of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesA small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease.Misfolded proteins in Alzheimer's disease and type II diabetes.Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activitiesReactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesAmyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's diseaseNovel drug targets based on metallobiology of Alzheimer's disease.Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity.A potential role for zinc alterations in the pathogenesis of Alzheimer's diseaseBiochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.Treatment strategies targeting amyloid β-protein.Werner coordination chemistry and neurodegeneration.The benzazole scaffold: a SWAT to combat Alzheimer's disease.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Selenoprotein P and selenoprotein M block Zn2+ -mediated Aβ42 aggregation and toxicity.3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Small bifunctional chelators that do not disaggregate amyloid β fibrils exhibit reduced cellular toxicity.Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.Mesoporous silica nanoparticle-based H2O2 responsive controlled-release system used for Alzheimer's disease treatment.Small molecule modulators of copper-induced Abeta aggregationUsing bacterial inclusion bodies to screen for amyloid aggregation inhibitors.Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide.Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.A rapid and efficient route to benzazole heterocycles.Femtosecond to nanosecond dynamics of 2,2'-bipyridine-3,3'-diol inside the nano-cavities of molecular containers.Selective fluorescence sensing of Cu(II) and Zn(II) using a new Schiff base-derived model compound: naked eye detection and spectral deciphering of the mechanism of sensory action.
P2860
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P2860
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Design, selection, and charact ...... cation in Alzheimer's disease.
@en
Design, selection, and charact ...... cation in Alzheimer's disease.
@nl
type
label
Design, selection, and charact ...... cation in Alzheimer's disease.
@en
Design, selection, and charact ...... cation in Alzheimer's disease.
@nl
prefLabel
Design, selection, and charact ...... cation in Alzheimer's disease.
@en
Design, selection, and charact ...... cation in Alzheimer's disease.
@nl
P2093
P50
P356
P1476
Design, selection, and charact ...... cation in Alzheimer's disease.
@en
P2093
Angel Alvarez-Larena
Pilar González-Duarte
Vega Lloveras
P304
P356
10.1021/JA806062G
P407
P50
P577
2009-02-01T00:00:00Z