Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamicsCross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenanceGenome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionVismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesisEarly phase clinical trials of anticancer agents in children and adolescents - an ITCC perspective.Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptorPituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere culturesCurcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo.Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathwaysTargeting Hedgehog--a cancer stem cell pathwayDexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastomaAmide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.Arsenic: a potentially useful poison for Hedgehog-driven cancers.Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal lifeHedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.Identification of small molecule activators of BMP signalingRapid diagnosis of medulloblastoma molecular subgroups.Overcoming resistance to Sonic Hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.Sonic hedgehog regulates osteoblast function by focal adhesion kinase signaling in the process of fracture healing.An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects.Basal cell carcinomas: attack of the hedgehog.Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate.Hedgehog pathway as a drug target: Smoothened inhibitors in development.Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy.Mouse models and mouse supermodels.Vismodegib.Automated volumetric growth plate measurement using magnetic resonance imaging for monitoring skeletal toxicity in children treated on investigational drug trials.Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young miceHedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment.Targeting developmental pathways in children with cancer: what price success?Hedgehog signaling in prostate cancer and its therapeutic implicationDrugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathwaysHedgehog-Gli signaling pathway inhibitors as anticancer agents.Genetically engineered mouse models of brain cancer and the promise of preclinical testing
P2860
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P2860
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Transient inhibition of the He ...... ent defects in bone structure.
@en
Transient inhibition of the He ...... ent defects in bone structure.
@nl
type
label
Transient inhibition of the He ...... ent defects in bone structure.
@en
Transient inhibition of the He ...... ent defects in bone structure.
@nl
prefLabel
Transient inhibition of the He ...... ent defects in bone structure.
@en
Transient inhibition of the He ...... ent defects in bone structure.
@nl
P1433
P1476
Transient inhibition of the He ...... ent defects in bone structure.
@en
P2093
Hiromichi Kimura
Jessica M Y Ng
P304
P356
10.1016/J.CCR.2008.01.027
P50
P577
2008-03-01T00:00:00Z