Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. - Wikidata - awgldk - TriplyDB

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

http://www.wikidata.org/entity/Q46461914

about

Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.The complex molecular biology of amyotrophic lateral sclerosis (ALS)The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains TAR DNA-binding protein 43 in neurodegenerative disease.Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution.Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration.Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies.TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies A fruitful endeavor: modeling ALS in the fruit fly Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72 Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins Molecular neuropathology of TDP-43 proteinopathies.RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases.Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: a potential role for caspases.The molecular basis of frontotemporal dementia.Dendritic retraction, but not atrophy, is consistent in amyotrophic lateral sclerosis-comparison between Onuf's neurons and other sacral motor neurons.Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans.TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.Protein aggregation in amyotrophic lateral sclerosis.RNA metabolism in ALS: when normal processes become pathological.A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells.Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils.

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P2860

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

http://www.wikidata.org/entity/Q46461914

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-my

2008年学术文章

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2008年學術文章

@yue

2008年學術文章

@zh-hant

name

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@en

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@nl

type

label

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@en

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@nl

prefLabel

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@en

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@nl

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J.FEBSLET.2008.07.027

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P1476

Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS.

@en

P2093

Francisco E Baralle

http://www.w3.org/2001/XMLSchema#string

Haruhiko Akiyama

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Mari Yoshida

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Masato Hasegawa

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Shin-ichi Hisanaga

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Tetsuaki Arai

http://www.w3.org/2001/XMLSchema#string

Yoshio Hashizume

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Yuki Inukai

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P2860

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases.

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

TDP-43 A315T mutation in familial motor neuron disease.

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2899-2904

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19

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582

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Emanuele Buratti

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2008-07-24T00:00:00Z

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51429570

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18656473

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amyotrophic lateral sclerosis

phosphorylation