The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
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A THEMIS:SHP1 complex promotes T-cell survivalT cell activationThe Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and DiseaseA conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signalingStructural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor ActivityRegulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubT cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.Nck recruitment to the TCR required for ZAP70 activation during thymic development.Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.Nck adapter proteins: functional versatility in T cellsThe CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cellsNovel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45Organization of proximal signal initiation at the TCR:CD3 complex.Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell developmentThe cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions.Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases.SNX17 affects T cell activation by regulating TCR and integrin recyclingBasic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.Ncking BCR-mediated PI3K activation.SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells.Insights into the initiation of TCR signaling.Molecular and genetic parameters defining T-cell clonal selection.The Allostery Model of TCR Regulation.Early T-cell activation biophysics.A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey.CD3ε recruits Numb to promote TCR degradation.Conformational changes in the T cell receptor differentially determine T cell subset development in mice.Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signalingLabel-free monitoring of T cell activation by the impedance-based xCELLigence system.Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor.Selected signalling proteins recruited to the T-cell receptor-CD3 complex.Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.TCR Signaling: Mechanisms of Initiation and Propagation.
P2860
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P2860
The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@en
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@nl
type
label
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@en
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@nl
prefLabel
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@en
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@nl
P2093
P2860
P50
P356
P1433
P1476
The proline-rich sequence of C ...... selection CD4+CD8+ thymocytes.
@en
P2093
Amandine Sansoni
Claude Grégoire
Michaël Mingueneau
P2860
P304
P356
10.1038/NI.1608
P407
P577
2008-04-13T00:00:00Z