Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.
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mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity.Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90Structure of the N-terminal Gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysisHoloenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VIA domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase functionStructure of a topoisomerase II–DNA–nucleotide complex reveals a new control mechanism for ATPase activityMycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motionThe ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogueThe use of divalent metal ions by type II topoisomerases.The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.Targeting the transposase domain of the DNA repair component Metnase to enhance chemotherapyDietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.E. coli Gyrase Fails to Negatively Supercoil Diaminopurine-Substituted DNA.Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndromeProbing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry.PTEN stabilizes TOP2A and regulates the DNA decatenationRestoration of topoisomerase 2 function by complementation of defective monomers in DrosophilaCytotoxic effect and molecular docking of 4-ethoxycarbonylmethyl-1-(piperidin-4-ylcarbonyl)-thiosemicarbazide--a novel topoisomerase II inhibitor.The role of ATP-dependent machines in regulating genome topology.Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.DNA topoisomerase II, genotoxicity, and cancerAnalysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspectiveA "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.Structural frameworks for considering microbial protein- and nucleic acid-dependent motor ATPases.DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.DNA topoisomerase II and its growing repertoire of biological functions.Antiviral activity of (+)-rutamarin against Kaposi's sarcoma-associated herpesvirus by inhibition of the catalytic activity of human topoisomerase II.Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs.Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.DNA topoisomerase-targeting chemotherapeutics: what's new?The role of monovalent cations in the ATPase reaction of DNA gyrase.Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibitionIntegrating molecular docking, DFT and CoMFA/CoMSIA approaches for a series of naphthoquinone fused cyclic α-aminophosphonates that act as novel topoisomerase II inhibitors.Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.SMS 2.0: an updated database to study the structural plasticity of short peptide fragments in non-redundant proteins.Discovery of mono- and disubstituted 1H-pyrazolo[3,4]pyrimidines and 9H-purines as catalytic inhibitors of human DNA topoisomerase IIα.
P2860
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P2860
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@en
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@nl
type
label
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@en
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@nl
prefLabel
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@en
Nucleotide-dependent domain mo ...... an type IIA DNA topoisomerase.
@nl
P2093
P2860
P356
P1476
Nucleotide-dependent domain mo ...... man type IIA DNA topoisomerase
@en
P2093
Gregory L Verdine
Seth K Bechis
P2860
P304
37041-37047
P356
10.1074/JBC.M506520200
P407
P577
2005-08-12T00:00:00Z