Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. - Wikidata - awgldk - TriplyDB

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

http://www.wikidata.org/entity/Q46797053

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Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function Autoregulation of Parkin activity through its ubiquitin-like domain ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin Parkin Regulation and Neurodegenerative Disorders Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models Pathologic and therapeutic implications for the cell biology of parkin S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1 alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease Organochlorine pesticide levels and risk of Parkinson's disease in north Indian population How Parkinsonian toxins dysregulate the autophagy machinery Pesticides, microglial NOX2, and Parkinson's disease Parkin is protective against proteotoxic stress in a transgenic zebrafish model Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain The effects of oxidative stress on parkin and other E3 ligases.The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons.MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.Role of the ubiquitin proteasome system in Parkinson's disease.Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.Mechanisms of Parkinson's disease-related proteins in mediating secondary brain damage after cerebral ischemia.Identification and characterization of a novel endogenous murine parkin mutation.Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Molecular mechanisms of pesticide-induced neurotoxicity: Relevance to Parkinson's disease.Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6 Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination Mitochondrial dynamics and Parkinson's disease: focus on parkin.The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.6-Hydroxydopamine induces mitochondrial ERK activation.Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.Expanding insights of mitochondrial dysfunction in Parkinson's disease.Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria?

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P2860

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

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Human Molecular Genetics

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Bobby Thomas

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Cheng Wang

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Fai Tsang

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Han Seok Ko

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Juan Troncoso

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Kah-Leong Lim

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Katherine C M Chew

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Michelle W L Ho

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Olga Pletnikova

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Shiam-Peng Tay

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P2860

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Molecular pathways of neurodegeneration in Parkinson's disease

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10.1093/HMG/DDI413

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24

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14

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16278233

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