p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
about
Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseThe Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival?Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathwayEnhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cellsInduction and inhibition of the pan-nuclear gamma-H2AX response in resting human peripheral blood lymphocytes after X-ray irradiationIs activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?Senescence and p130/Rbl2: a new beginning to the end.Apoptotic capacity and risk of squamous cell carcinoma of the head and neck.Enhanced γ-H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry.Multispectral imaging flow cytometry reveals distinct frequencies of γ-H2AX foci induction in DNA double strand break repair defective human cell lines.Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells.Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.Transcriptional activation of p21Waf1 contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin.Sequential administration of camptothecin sensitizes human colon cancer HCT116 cells to paclitaxel via p21Cip1/WAF1
P2860
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P2860
p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-hans
2006年学术文章
@zh-my
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2006年學術文章
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name
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
@en
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
@nl
type
label
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
@en
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
@nl
prefLabel
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
@en
p21CDKN1A allows the repair of ...... ibitor 7-hydroxystaurosporine.
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P2093
P2860
P356
P1433
P1476
p21CDKN1A allows the repair of ...... hibitor 7-hydroxystaurosporine
@en
P2093
H Takemura
M I Aladjem
R L Hayward
W M Bonner
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209313
P407
P577
2006-05-01T00:00:00Z