Control of peptide deformylase activity by metal cations.
about
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayHuman mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsAmine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloningIdentification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanismsAntibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase InhibitorCrystal structure of type II peptide deformylase from Staphylococcus aureusStructural variation and inhibitor binding in polypeptide deformylase from four different bacterial speciesEukaryotic peptide deformylases. Nuclear-encoded and chloroplast-targeted enzymes in ArabidopsisPeptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach.Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents.N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activityPeptide deformylase: a target for novel antibiotics?The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.Peptide deformylase inhibitors as potent antimycobacterial agents.Therapeutic potential of peptide deformylase inhibitors.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin.A unique peptide deformylase platform to rationally design and challenge novel active compounds.The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.Signal recognition particle prevents N-terminal processing of bacterial membrane proteins.The activity and cofactor preferences of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) change depending on environmental conditions.A new synthetic route to N-benzyl carboxamides through the reverse reaction of N-substituted formamide deformylase.Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.Geometric preferences in iron(II) and zinc(II) model complexes of peptide deformylase.Type 3 peptide deformylases are required for oxidative phosphorylation in Trypanosoma brucei.p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils.Energetic rationale for an unexpected and abrupt reversal of guanidinium chloride-induced unfolding of peptide deformylaseDynamic enzyme docking to the ribosome coordinates N-terminal processing with polypeptide folding.Ion mobility coupled to native mass spectrometry as a relevant tool to investigate extremely small ligand-induced conformational changes.The proteomics of N-terminal methionine cleavage.
P2860
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P2860
Control of peptide deformylase activity by metal cations.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Control of peptide deformylase activity by metal cations.
@en
Control of peptide deformylase activity by metal cations.
@nl
type
label
Control of peptide deformylase activity by metal cations.
@en
Control of peptide deformylase activity by metal cations.
@nl
prefLabel
Control of peptide deformylase activity by metal cations.
@en
Control of peptide deformylase activity by metal cations.
@nl
P356
P1476
Control of peptide deformylase activity by metal cations.
@en
P2093
P304
P356
10.1006/JMBI.1998.1883
P407
P577
1998-07-01T00:00:00Z