Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.
about
Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanismsThe TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expressionRegulation of amyloid precursor protein processing by its KFERQ motif.The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative DiseasesTREM2-Ligand Interactions in Health and Disease.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathwayProteomics as an innovative tool to investigate frontotemporal disorders.Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's diseaseContributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defectsNeurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.Intracellular trafficking of TREM2 is regulated by presenilin 1.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.Vps35-dependent recycling of Trem2 regulates microglial function.Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson’s Disease.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein StabilityLoss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
P2860
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P2860
Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
@zh
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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2015年學術文章
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name
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@en
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@nl
type
label
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@en
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@nl
prefLabel
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@en
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@nl
P2093
P2860
P356
P1433
P1476
Disease-Associated Mutations o ...... arides in the Golgi Apparatus.
@en
P2093
Dong-Hou Kim
In Jung Ji
Ji-Seon Park
Min-Ji Kang
Sang-Wook Kang
Seung-Yong Yoon
P2860
P304
P356
10.1111/TRA.12264
P50
P577
2015-02-24T00:00:00Z