Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter. - Wikidata - awgldk - TriplyDB

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.

http://www.wikidata.org/entity/Q48573474

about

Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation Monoamine transporters: insights from molecular dynamics simulations Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transporters Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates X-ray structures of LeuT in substrate-free outward-open and apo inward-open states Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations Ligand effects on cross-linking support a conformational mechanism for serotonin transport.The N terminus of monoamine transporters is a lever required for the action of amphetamines Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Cytoplasmic permeation pathway of neurotransmitter transporters.The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Probing binding pocket of serotonin transporter by single molecular force spectroscopy on living cells.Unifying concept of serotonin transporter-associated currents Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol.Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1)Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog Mechanism for alternating access in neurotransmitter transporters.Thermostabilisation of the serotonin transporter in a cocaine-bound conformation.Control of serotonin transporter phosphorylation by conformational state.Inside job: ligand-receptor pharmacology beneath the plasma membrane.Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.Structural perspectives on secondary active transporters.Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer.Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells.Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation.Biophysical Approaches to the Study of LeuT, a Prokaryotic Homolog of Neurotransmitter Sodium Symporters.Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation.Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

P2860

Q21132475-E8149B4A-5940-4AEC-93D8-42BF1F96D5C2 Q26777242-1983238A-06DD-481D-A04A-4697F072DE85 Q26825537-A134972B-649F-4F37-A906-F8022858851D Q26829749-D7444109-1AF2-4E4D-9DB5-B536BFC59645 Q26853319-35847553-B2A1-499C-A536-B1E7DD1A2FEA Q27676655-F6F0A7C8-7B76-444F-9E7C-6D0D7988DF7A Q28533835-149F5E6D-DCAF-4204-AC71-F008B1E9A973 Q33553309-D2EDC4F9-1D71-4059-AEAC-E6DE95E5C17A Q33796294-4D5C99B4-F8A8-499A-9E39-D3B5E2F349FF Q34064167-D5DA0B15-8FE6-4078-B9FB-4313CB4D7C23 Q34137102-733FD210-F0DF-4ADE-BEE5-39F0A0C8CF87 Q34202128-27024C2B-9088-4CE5-871F-FF938D6DFEEC Q34660686-45815F01-3276-4554-B113-AF906A044EE8 Q34825605-AE97B64C-F3A6-4E71-933F-6D4A3965CE4A Q35016767-8145FD5F-1936-4DB1-97F5-691D3529A22C Q35643579-73C14347-B545-44A2-BE29-55C9FBFC6222 Q35643721-16538667-7B07-4A18-BF36-FA2156945EF6 Q35975646-1A9CCCF2-77D8-4AAC-9906-BD59B5D5E976 Q36006806-7B6525C5-E78C-44A6-BDCA-ABBF078E70DA Q36432395-18B7578B-188F-4987-96A1-05AB5C634FFF Q36466214-A3DC2AB3-5907-4AEB-A850-F5BC10F555DF Q36785076-2CEE38B8-996C-4594-AB8C-DF187765F7FB Q36917238-9B401F0B-69FF-4FA4-971E-DF585BB3C490 Q36930972-CD7B5367-185F-4499-AD28-2BDC5F30EC7C Q36989788-C5A49981-12C6-42A9-8D40-3C39AFEEE0FB Q37451183-685926F4-1D6A-4B7F-9561-63074390D242 Q37775229-40B70D15-4239-4A4D-8937-B9652F19BB19 Q38949208-7CAF4270-DC0B-44C9-9461-96FAE7DFCDEA Q39459667-E12EB869-D98A-4CFD-8449-3E0474EF98E0 Q39551874-27535836-7462-42FE-BE17-8C44902BA44B Q39809302-967C770A-037C-4E71-817C-9A9A36633E02 Q41027994-CD3219FA-63DD-440F-88D6-7503D9DBEEA3 Q41175275-0FDE0E65-EAD1-4FC0-82FD-5083AF25206F Q41536585-ADC160E9-7DE5-47C2-AB13-ABE9603477FA Q41549350-2E195DFB-3CAA-45B4-9F9D-9846B052545D Q41861390-DAC3786E-AA87-4347-A249-303FDC73AEA1 Q41970582-EB904F6C-8D87-48AF-B755-6320F68822D3 Q42133017-A34E9216-3639-46FD-A727-32E6F1B3F5EC Q42249280-412029E0-7AC4-48DA-93E7-60A5FEF52CAB Q42272217-09CD7EFF-50DD-486C-958C-7B3CDF1F94F8

P2860

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.

http://www.wikidata.org/entity/Q48573474

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh

2007年學術文章

@zh-hant

name

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@en

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@nl

type

label

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@en

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@nl

prefLabel

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@en

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@nl

P1433

Q48573474-99C9136C-2F06-44E8-9483-F3E4DC3567F2

P1476

Q48573474-24EE56B1-ADD6-4084-885F-13E78AB17F6C

P2093

Q48573474-2FFA86D5-C982-4A58-8FEB-0E4DE189549D

Q48573474-498FE1FA-AC12-4E0E-AFEF-C0E3D2881C54

Q48573474-9A63DDF5-E39F-4C78-8E6E-F92EFA059504

Q48573474-D9491D00-D602-4E62-B408-0FA13B3351B6

P2860

Q48573474-06BAAF18-A52C-432F-83E3-BD04B134B2A1

Q48573474-0E3D1FDE-D03B-49C6-8CFF-1EAB8D8B6395

Q48573474-0F860ABC-ECFE-40AD-A187-23F0641540B8

Q48573474-1294E0DE-058C-4B54-B730-195D48AE2D1C

Q48573474-34BF707E-DFDF-4E05-96CE-8FEFE8621022

Q48573474-4B835B50-EDAD-4694-A993-4FD2557C6D76

Q48573474-542A89F3-1309-4FC1-B033-29813CACAAD5

Q48573474-79C83049-2A13-4A1C-99DD-F9856BB619B8

Q48573474-8CD15ED6-FAB4-4048-B809-472480A705F7

Q48573474-A86DD393-01F5-46FC-AEBB-8149BE05390C

P304

Q48573474-960D78C0-2651-4A63-95BC-349E2DEC3EE0

P31

Q48573474-05C6256D-8DD1-4C57-AB3B-AF53AA765CA0

P356

Q48573474-3E2BF8AB-2330-4EE6-B195-D50F335F7A33

P407

Q48573474-9B580D5D-207D-43CD-9A0B-8628231BAF54

P433

Q48573474-861AC317-CE7D-4120-AA66-C354D1021267

P478

Q48573474-F5CB13A6-413F-451C-9F06-AEC8D32C501D

P577

Q48573474-78D2632F-2042-4D95-97D5-2FDECF671E53

P5875

Q48573474-C44D272A-A2B5-4356-B0A5-A5C71B746153

P698

Q48573474-DD4F7518-93BC-4A14-A27E-4651FE4C89DC

P921

Q48573474-1A8D6665-593F-4F27-9146-68E0645AED6D

Q48573474-88a87464-efa9-41d9-bc4b-dbc0bb2ab244

P356

P1433

Journal of Biological Chemistry

P1476

Ibogaine, a noncompetitive inh ...... cing state of the transporter.

@en

P2093

Gary Rudnick

http://www.w3.org/2001/XMLSchema#string

Miriam T Jacobs

http://www.w3.org/2001/XMLSchema#string

Scott D Campbell

http://www.w3.org/2001/XMLSchema#string

Yuan-Wei Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline.

Antibody evidence for different conformational states of ADP, ATP translocator protein isolated from mitochondria

Identification of a chloride ion binding site in Na+/Cl -dependent transporters.

From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters.

Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.

Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.

Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis.

P304

29441-29447

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M704456200

http://www.w3.org/2001/XMLSchema#string

P407

P433

40

http://www.w3.org/2001/XMLSchema#string

P478

282

http://www.w3.org/2001/XMLSchema#string

P577

2007-08-13T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6140500

http://www.w3.org/2001/XMLSchema#string

P698

17698848

http://www.w3.org/2001/XMLSchema#string

P921