GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.
about
A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sitesA novel class of ligand-gated ion channel is activated by Zn2+Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neuronsProton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domainDecreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexiaGeneral anaesthetic actions on ligand-gated ion channels5-HT3 receptorsActivation of single heteromeric GABA(A) receptor ion channels by full and partial agonistsChannel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segmentPentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepinesButalbital in the treatment of headache: history, pharmacology, and efficacyIdentification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous openingIdentification of amino acids in the glutamate receptor, GluR3, important for antibody-binding and receptor-specific activationPrinciples of agonist recognition in Cys-loop receptorsAllosteric activation mechanism of the cys-loop receptorsMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelEffects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combinationPositive allosteric modulation by ultraviolet irradiation on GABA(A), but not GABA(C), receptors expressed in Xenopus oocytesMicroscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunitRat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinitiesMechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure.Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory.GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing.Hearing loss alters the subcellular distribution of presynaptic GAD and postsynaptic GABAA receptors in the auditory cortex.Hearing loss prevents the maturation of GABAergic transmission in the auditory cortexPhoto-antagonism of the GABAA receptor.An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.Molecular and functional diversity of the expanding GABA-A receptor gene family.New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform.Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation.Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsAllosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsZinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.
P2860
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P2860
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@en
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@nl
type
label
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@en
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@nl
prefLabel
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@en
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@nl
P356
P1433
P1476
GABAA receptor needs two homol ...... GABA but not by pentobarbital.
@en
P2888
P304
P356
10.1038/366565A0
P407
P577
1993-12-01T00:00:00Z
P6179
1023497383