Molecular localization of an ion-binding site within the pore of mammalian sodium channels.
about
Using the deadly mu-conotoxins as probes of voltage-gated sodium channelsBlock of sodium channels by divalent mercury: role of specific cysteinyl residues in the P-loop region.High-affinity Zn block in recombinant N-methyl-D-aspartate receptors with cysteine substitutions at the Q/R/N site.External K(+) relieves the block but not the gating shift caused by Zn(2+) in human Kv1.5 potassium channelsGenetically engineered metal ion binding sites on the outside of a Channel's transmembrane beta-barrel.Is there more than one way to skin a newt? Convergent toxin resistance in snakes is not due to a common genetic mechanism.Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesFunctional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels.Structure of the sodium channel pore revealed by serial cysteine mutagenesis.Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Na v 1.7 sodium channels.Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.Cloning of a sodium channel alpha subunit from rabbit Schwann cells.Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesisPore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.Mechanisms of sodium/calcium selectivity in sodium channels probed by cysteine mutagenesis and sulfhydryl modification.The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field.Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels.Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation.On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel.A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.Permeation of Na+ through open and Zn(2+)-occupied conductance states of cardiac sodium channels modified by batrachotoxin: exploring ion-ion interactions in a multi-ion channelAn engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding.Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids.Potassium transport in the mammalian collecting duct.Trimethyloxonium modification of batrachotoxin-activated Na channels alters functionally important protein residuesA mutation in the pore of the sodium channel alters gating.Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes.Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.Structure and function of voltage-gated sodium channels.Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.A method to measure myocardial calcium handling in adult DrosophilaMechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Sodium channel inactivation goes with the flowCharged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.
P2860
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P2860
Molecular localization of an ion-binding site within the pore of mammalian sodium channels.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Molecular localization of an i ...... of mammalian sodium channels.
@en
Molecular localization of an i ...... of mammalian sodium channels.
@nl
type
label
Molecular localization of an i ...... of mammalian sodium channels.
@en
Molecular localization of an i ...... of mammalian sodium channels.
@nl
prefLabel
Molecular localization of an i ...... of mammalian sodium channels.
@en
Molecular localization of an i ...... of mammalian sodium channels.
@nl
P2093
P356
P1433
P1476
Molecular localization of an i ...... of mammalian sodium channels.
@en
P2093
P304
P356
10.1126/SCIENCE.1321496
P407
P577
1992-07-01T00:00:00Z