Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells. - Wikidata - awgldk - TriplyDB

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

http://www.wikidata.org/entity/Q52828045

about

Calu-3 BICR 10 BICR 16 BICR 3 BICR 31 BICR 56 BICR 6 BICR 63 BICR 78 BICR 82 LS106 LS111 LS274 LS277 LS310

P1343

Identification of druggable cancer driver genes amplified across TCGA datasets High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration Focal adhesion kinase protein levels in gut epithelial motility Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.N-MYC regulates focal adhesion kinase expression in human neuroblastoma.The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study.The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells.Identification of MYST3 as a novel epigenetic activator of ERα frequently amplified in breast cancer.Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma Focal adhesion kinase: an alternative focus for anti-angiogenesis therapy in ovarian cancer.Functional kinomics identifies candidate therapeutic targets in head and neck cancer Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation.Comparative analysis of algorithms for integration of copy number and expression data.Chromosomal alterations in squamous cell carcinomas of the head and neck: window to the biology of disease.MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression Downregulation of Focal Adhesion Kinase (FAK) by cord blood stem cells inhibits angiogenesis in glioblastoma Adhesive mechanisms regulating invasion and metastasis in oral cancer.Pten signaling in gliomas.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights Focal adhesion kinase as a potential target in oncology.FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells FIP200, a key signaling node to coordinately regulate various cellular processes.cAMP Elevation Down-Regulates β3 Integrin and Focal Adhesion Kinase and Inhibits Leptin-Induced Migration of MDA-MB-231 Breast Cancer Cells.Specific induction of pp125 focal adhesion kinase in human breast cancer.FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma.Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness.Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma Progress in researches about focal adhesion kinase in gastrointestinal tract.Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.Focal adhesion kinase and p53 signal transduction pathways in cancer.

P2860

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P1343

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P2860

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

http://www.wikidata.org/entity/Q52828045

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年學術文章

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1999年學術文章

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name

Increased dosage and amplifica ...... se gene in human cancer cells.

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Increased dosage and amplifica ...... se gene in human cancer cells.

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type

label

Increased dosage and amplifica ...... se gene in human cancer cells.

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Increased dosage and amplifica ...... se gene in human cancer cells.

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prefLabel

Increased dosage and amplifica ...... se gene in human cancer cells.

@en

Increased dosage and amplifica ...... se gene in human cancer cells.

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P1476

Increased dosage and amplifica ...... se gene in human cancer cells.

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P2093

Agochiya M

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Brunton VG

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Frame MC

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Keith WN

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Owens DW

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Paraskeva C

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Parkinson EK

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P2860

Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

Interaction of focal adhesion kinase with cytoskeletal protein talin

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

Cleavage of focal adhesion kinase by caspases during apoptosis

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

P2888

P304

5646-5653

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10.1038/SJ.ONC.1202957

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