Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
about
Advancing human health risk assessment: integrating recent advisory committee recommendationsTransgenic rat models for mutagenesis and carcinogenesisComparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.A mode-of-action approach for the identification of genotoxic carcinogens.MutAIT: an online genetic toxicology data portal and analysis tools.Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept StudyKinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO₃-Induced DNA Damage.Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report.Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cellsContributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure.Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.Changes in the Dose-Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant.The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.Locked nucleic acid (LNA): Based single-stranded oligonucleotides are not genotoxic.Development of an in vitro PIG-A gene mutation assay in human cells.Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans.Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations.Setting Occupational Exposure Limits for Genotoxic Substances in the Pharmaceutical Industry.International regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.Dose-response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay.Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent.Phenolphthalein induces centrosome amplification and tubulin depolymerization in vitro.Influence of DNA repair on nonlinear dose-responses for mutation.Global regulatory requirements for mutagenicity assessment in the registration of industrial chemicals.Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.Is received dose from ingested soil independent of soil PAH concentrations?-Animal model results.A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.Estimating the carcinogenic potency of chemicals from the in vivo micronucleus test.Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay.Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.Genotoxic and teratogenic effect of freshwater sediment samples from the Rhine and Elbe River (Germany) in zebrafish embryo using a multi-endpoint testing strategy.
P2860
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P2860
Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Quantitative approaches for as ...... in genetic toxicology studies.
@en
Quantitative approaches for as ...... in genetic toxicology studies.
@nl
type
label
Quantitative approaches for as ...... in genetic toxicology studies.
@en
Quantitative approaches for as ...... in genetic toxicology studies.
@nl
prefLabel
Quantitative approaches for as ...... in genetic toxicology studies.
@en
Quantitative approaches for as ...... in genetic toxicology studies.
@nl
P2093
P2860
P356
P1476
Quantitative approaches for as ...... in genetic toxicology studies.
@en
P2093
A M Jeffrey
B B Gollapudi
D P Lovell
J T Macgregor
J van Benthem
K L Dearfield
L G Hernandez
P2860
P356
10.1002/EM.21727
P577
2012-09-18T00:00:00Z