In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. - Wikidata - awgldk - TriplyDB

In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.

In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.

http://www.wikidata.org/entity/Q53586381

about

Immune surveillance for ERAAP dysfunction Antigenic peptide trimming by ER aminopeptidases--insights from structural studies Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses From HLA-B27 to spondyloarthritis: a journey through the ER.Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Pathways of antigen processing.Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1 An overview of genetics of paediatric rheumatic diseases.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Proteases in MHC class I presentation and cross-presentation The carboxypeptidase ACE shapes the MHC class I peptide repertoire Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses Portable flanking sequences modulate CTL epitope processing.Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Constitutive and inflammatory immunopeptidome of pancreatic β-cells.Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1 Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes Coping with loss of perfection in the MHC class I peptide repertoire.ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1 Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.HLA-B27 misfolding and spondyloarthropathies.Don't mess with ERAAP!Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.MHC class I assembly: out and about.

P2860

Q26862723-EEC477AB-8E8E-46F0-95AF-82168A61A1B2 Q27009465-F06D2B93-3600-433B-AD0B-7AF59EE7B7DE Q27310960-FE2084DA-1802-44F2-8230-714A1D2D8F11 Q27670921-21ACA192-4CBB-49B8-A043-A1AB8F9EC313 Q27680633-F5547168-3D7A-4AF4-B2F3-7882573B15D8 Q27687662-172FAF86-6998-4084-BBCA-A913B0F43CB4 Q28941251-0F426D3F-39AD-46C1-8809-9678A3D56275 Q33382992-AE271A67-5D05-41FC-A382-623E44977FDE Q33631854-2F105959-464C-4256-A932-09EA0E357BBA Q33688037-0707B559-D6DD-4A94-AB17-BAAFEB031EAF Q33728652-4C998BAB-FEB4-4BC1-B184-65E9FD6BAEF3 Q33791476-BC04B915-62AD-4159-BA24-598EB65DD020 Q33807043-E8B9ABA2-5D06-44E4-9162-E7306238777C Q34023384-5D60EFB0-E610-4AC8-AA29-068DD6A79A54 Q34363289-B9CBBF23-47A9-46E7-A888-FD2C234A4F43 Q34741321-08698B72-36B5-4DB4-A3CB-DCF434AFF7DB Q34921343-A0F5EEE8-558E-405C-A9B6-709B834D6FCD Q34979864-263EE12A-7902-49B4-9A51-1A309E877C82 Q35402189-AC80406C-6462-4425-A463-29735257225A Q36018570-825306AD-70FE-4047-B076-974D564D65BE Q36072282-E8CAE99C-037B-43FE-9BDA-D45BC1B5839A Q36099407-AE976FDA-06ED-4906-B4CA-11036615B889 Q36104800-DC56A66E-8B09-468C-82DE-52ADA17359AE Q36197201-0E3870AB-5C22-4060-AAAC-2ADB92464C00 Q36246044-EBABE99B-FE52-44BE-99C0-13F5DB749AB9 Q36339503-7D0C652E-680C-414E-B1C4-EAC8E596F082 Q36479743-49DA1F07-8583-419B-ABC0-AF8858453577 Q36509997-9D7CCD8A-A3F8-4669-87A5-5CCF43B04622 Q36646587-708E14D4-76C5-475F-AE18-C85836588AE7 Q36799097-6BE78645-BA1A-4013-B7F4-435402E7987B Q36853385-461A6C9B-832C-4023-BD1E-9EDF3E165704 Q37075162-CFF7B643-6ABA-462D-B38D-7481573F7D44 Q37076211-45F95676-9C44-4D53-BFC4-1F8E100480C1 Q37137155-8EDE666D-2094-48F9-B471-974C7E7D3991 Q37158031-AF7A5C64-87D9-410F-9D19-801847A7FF57 Q37168911-3454D327-68D7-41A6-8243-BC27347BC1CB Q37178385-53DF34DD-95B5-425C-B2D8-F029D60587D8 Q37184256-EDDAA66C-6642-4121-97EF-D0F6AD3C7069 Q37202320-9F4957FA-4CBE-40B9-A490-5EFABFFCE13F Q37233583-48086CEB-5EB6-4AC0-A23F-9DFA911AA9EA

P2860

In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.

http://www.wikidata.org/entity/Q53586381

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

2006年學術文章

@zh-hant

name

In the absence of aminopeptida ...... d highly immunogenic peptides.

@en

In the absence of aminopeptida ...... d highly immunogenic peptides.

@nl

type

label

In the absence of aminopeptida ...... d highly immunogenic peptides.

@en

In the absence of aminopeptida ...... d highly immunogenic peptides.

@nl

prefLabel

In the absence of aminopeptida ...... d highly immunogenic peptides.

@en

In the absence of aminopeptida ...... d highly immunogenic peptides.

@nl

P1433

Q53586381-AD1818FA-47A0-4196-9960-9D086228D063

P1476

Q53586381-A242584D-C51A-4E0B-972A-594C58E11BBD

P2093

Q53586381-161B32B0-1B26-4409-93C4-EFC6F9F10427

Q53586381-3350D32A-8207-4FAB-BACB-613730962840

Q53586381-A866F2D1-D40B-49D4-88B8-B25D85DD3EDF

Q53586381-CC85D31B-AA6F-4F25-84A1-12CC7A496101

Q53586381-D36C8481-BFAD-46B0-9012-C1CB0FF5E459

P2860

Q53586381-00999E7B-047A-46D8-8B95-1727AF2BC9BD

Q53586381-0415DC99-E1AB-4965-8210-FFD958146998

Q53586381-0BE193D4-531B-4E37-B816-001AB9E1BAF3

Q53586381-1900E9BE-448A-4F82-86CF-8276C113314E

Q53586381-2004BE9E-DC48-440F-899A-C0DA85CDE132

Q53586381-27994591-352A-47B4-BF62-F26E2FEBE3E2

Q53586381-337C8EA5-405A-4A35-A760-2DE8E0FCB7AC

Q53586381-3560979F-FF08-47F1-8DE0-8D603119140D

Q53586381-38A6529C-5F0A-4E0A-BA60-C1CC8052ACD4

Q53586381-3EC65DDE-115B-48AB-BF67-4CA9611065BA

P304

Q53586381-4C9757E2-481B-45B1-B9B4-72979E93539B

P31

Q53586381-D1173B58-B337-4DFB-A233-94B21194506D

P356

Q53586381-03F4480C-241A-4A89-959D-BF614B23EAA9

P407

Q53586381-2D2077A3-B24E-4F1A-8A1E-9869933CF5E6

P433

Q53586381-4F067D40-7A66-4057-A4F2-B4CC15C58F16

P478

Q53586381-9AE38DC6-B7DF-43D2-8395-76629A9093B6

P577

Q53586381-66AB2288-CF61-4122-965D-5C1BC56AE5C4

P5875

Q53586381-5CEA392B-F660-4650-B47B-1DAC44C75390

P698

Q53586381-B5AFC246-03F6-496A-9289-B0F3314AE6E4

P356

P1433

Nature Immunology

P1476

In the absence of aminopeptida ...... d highly immunogenic peptides.

@en

P2093

Edward James

http://www.w3.org/2001/XMLSchema#string

Federico Gonzalez

http://www.w3.org/2001/XMLSchema#string

Gianna Elena Hammer

http://www.w3.org/2001/XMLSchema#string

Hector Nolla

http://www.w3.org/2001/XMLSchema#string

Nilabh Shastri

http://www.w3.org/2001/XMLSchema#string

P2860

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

The molecular basis of allorecognition

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells

Quantitative and qualitative influences of tapasin on the class I peptide repertoire.

Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules.

The nature of the MHC class I peptide loading complex.

Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel.

P304

101-108

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NI1409

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P577

2006-11-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6670548

http://www.w3.org/2001/XMLSchema#string

P698

17128277

http://www.w3.org/2001/XMLSchema#string