Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. - Wikidata - awgldk - TriplyDB

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

http://www.wikidata.org/entity/Q53628145

about

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease Trafficking and proteolytic processing of APP The canonical Notch signaling pathway: unfolding the activation mechanism.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells.Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Mutant presenilin 1 increases the expression and activity of BACE1 The many substrates of presenilin/γ-secretase.Amyloid precursor protein processing and Alzheimer's disease Amyloid-β production: major link between oxidative stress and BACE1.The physiology of the β-amyloid precursor protein intracellular domain AICD.The role of Adams in Notch signaling.The very many faces of presenilins and the γ-secretase complex.Biological function of Presenilin and its role in AD pathogenesis Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution.Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2 Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

P2860

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P2860

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

http://www.wikidata.org/entity/Q53628145

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

2006年學術文章

@zh

2006年學術文章

@zh-hant

name

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@en

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@nl

type

label

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@en

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@nl

prefLabel

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@en

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@nl

P1433

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P1433

P1476

Presenilin-dependent gamma-sec ...... omes is functionally distinct.

@en

P2093

Akiko Ikuta

http://www.w3.org/2001/XMLSchema#string

Akio Fukumori

http://www.w3.org/2001/XMLSchema#string

Hisashi Tanii

http://www.w3.org/2001/XMLSchema#string

Jingwei Jiang

http://www.w3.org/2001/XMLSchema#string

Kanta Yanagida

http://www.w3.org/2001/XMLSchema#string

Kojin Kamino

http://www.w3.org/2001/XMLSchema#string

Masatoshi Takeda

http://www.w3.org/2001/XMLSchema#string

Naohiro Itoh

http://www.w3.org/2001/XMLSchema#string

Shinji Tagami

http://www.w3.org/2001/XMLSchema#string

Taisuke Nakayama

http://www.w3.org/2001/XMLSchema#string

P304

4907-4914

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/BI052412W

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

45

http://www.w3.org/2001/XMLSchema#string

P50

Christian Haass

Masayasu Okochi

P577

2006-04-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16605258

http://www.w3.org/2001/XMLSchema#string