Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 - Wikidata - awgldk - TriplyDB

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

http://www.wikidata.org/entity/Q36421137

about

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase Receptor tyrosine kinases in the nucleus Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin The canonical Notch signaling pathway: unfolding the activation mechanism.Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase Notch inhibitors for cancer treatment.The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.Not(ch) just development: Notch signalling in the adult brain.An overview of notch signaling in adult tissue renewal and maintenance.The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis Real-time imaging of notch activation with a luciferase complementation-based reporter.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.Notch signaling from the endosome requires a conserved dileucine motif.Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations Presenilin: RIP and beyond.Presenilins: members of the gamma-secretase quartets, but part-time soloists too.Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination.The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development Trafficking of receptor tyrosine kinases to the nucleus Endocytic regulation of Notch signaling.The role of protease activity in ErbB biology.The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila.Membrane tethered delta activates notch and reveals a role for spatio-mechanical regulation of the signaling pathway.Targeting Notch to target cancer stem cells.The multiple facets of ubiquitination in the regulation of notch signaling pathway.Proteolytic cleavage of Notch: "HIT and RUN".Intramembrane proteolysis in regulated protein trafficking.The role of endocytosis in activating and regulating signal transduction.The role of Adams in Notch signaling.Balanced ubiquitination determines cellular responsiveness to extracellular stimuli.Therapeutic modulation of Notch signalling--are we there yet?

P2860

Q24303928-1BCE899F-2F2A-4B53-BA46-377AB5BED119 Q24338376-7C459F08-2242-47ED-ADE4-7BB814194617 Q26830216-99482902-CE62-454F-8ABD-E7CCDBA28144 Q28595013-4BFAB2E6-BD50-4E27-B16B-0762EB1BCE8D Q29547725-0DE9DFAB-4112-4C1B-961F-FA6C10E15609 Q33673817-BAD687D7-DF87-4C44-99FD-B699222585D8 Q33840072-2054A91D-71A6-475D-80D7-08C8C2E013AD Q34057805-0D4E10AB-9D5B-4EA4-A48C-CF228AEFAE29 Q34126479-29B943CC-8DC3-43E1-8FC4-F76323A57215 Q34193760-C77DDB8D-AD89-4F7B-8D92-EB6728A140C0 Q34330869-B15BC24A-FEA8-492A-B52C-A94D721FC219 Q34422762-90C90101-6134-432B-825F-8F080186C746 Q34477370-6D2EC078-100E-4A74-92DE-F25C5861ACD0 Q34979489-E037D043-A932-4EA8-B35F-72FE96918BA5 Q34981717-F9C69218-CC6F-4886-B70E-13D2DCD0D7C0 Q35000965-AEE7FF27-CF44-4C3C-8476-DA67C5EB121D Q35175155-20525B94-BCAF-46E9-AA6B-46F9750FD13B Q35180702-63AE7380-02EF-4994-B9BE-685154120814 Q35878150-988D6D1E-4143-4EA6-9210-495A3B5F3CA5 Q36071418-F283B501-7178-4A59-B95B-CC39176E70F2 Q36294856-CB810D51-334E-495C-9917-D75F56540F02 Q36587968-BDAFDFF5-ADCE-4208-A7B1-DE14EA759C35 Q37010838-D938F30F-F7E0-4A98-82DC-AC61AA87922A Q37219819-1A30026A-197B-445F-B343-9B093DE88E65 Q37242236-6F99FA13-C2A5-493E-9BA9-6E542B66333A Q37259798-363861E2-5119-4EAB-9A7A-D33A0870D5DB Q37284219-0A3A8251-7DBF-4192-8E04-F1DCC2D8CD96 Q37308472-9A5BCA3F-C1A2-4532-BD93-42D178BD0801 Q37318272-2226DD5E-1B8E-4A41-BA62-27773F2F8A06 Q37326973-233989E3-6A2D-4A1E-A9E7-BFD117A92044 Q37378404-11A097C1-7325-4459-8A3B-D844740C3569 Q37440431-9917F84B-FC93-43A9-BFBF-458FD3ADD490 Q37763414-A0C17F00-C13C-4CF7-BE03-ED3B3634692D Q37804446-93A04215-936C-4251-BFF0-A2A2037BA681 Q37867140-731BD3F3-42BE-4F5F-B1BC-8AB2F8981F6F Q37876486-80E36C16-A593-4129-9AB3-C7A1F0BD2692 Q37960345-18FEAA6D-11EF-484F-B573-ECC989A0BA3F Q37991568-BDB50E07-CEAF-4521-A3E8-2220075057DA Q38028853-7EE1DC93-B82D-4045-8ED2-902841762F60 Q38208211-ECCA376C-DB80-4655-B5DD-A8043F5E6627

P2860

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

http://www.wikidata.org/entity/Q36421137

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

2007年學術文章

@zh

2007年學術文章

@zh-hant

name

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@ast

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@en

type

label

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@ast

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@en

prefLabel

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@ast

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@en

P1433

Q36421137-AA5F9133-F543-4671-A5FC-5A47928BD9E3

P1476

Q36421137-53E8EC20-D2D9-43A3-963B-33740AB3954B

P2093

Q36421137-05D14309-0243-4DB1-87B6-0519B5E9378C

Q36421137-154643A6-039D-4613-B0B9-F796C76FDCA0

Q36421137-2ED6B6F7-CE15-4268-BE7C-70D99F27C0A0

Q36421137-339CBD4B-BBE1-4214-8942-F2C45A09AD55

Q36421137-4520E2FF-0692-4A6E-9831-874BF917B450

Q36421137-4B0830C2-68FB-40C2-A3B2-AA154A368AB9

Q36421137-6CFDCC28-5923-436D-8A74-375A007DE290

Q36421137-81DE722F-357A-4AEF-868F-E2DE2115995D

Q36421137-84AFCE6C-72AE-402B-903B-B2BA34E740DB

Q36421137-9CB2E68A-90A4-40FD-996F-F9666044B1F7

P2860

Q36421137-04D8D3F8-C6FE-4EEC-8F64-3C4C01FC1F6F

Q36421137-0BE54E0B-F1B7-46C5-9334-755541410353

Q36421137-187FE0FA-3F3D-42FB-AD8D-6211F0B386CA

Q36421137-1CAD4C38-77FC-4141-9EF1-57418CE5F321

Q36421137-1CB66718-DD29-44E9-8F44-2EAC693848EC

Q36421137-25B9F498-59EF-4FEB-81C8-45796ED52D36

Q36421137-2EA9C590-7687-4552-89A8-6A00F889C4E3

Q36421137-3CBADFE5-C507-443F-9018-7AB439E8E617

Q36421137-4BC29212-5956-46D6-8E97-049843ECBB7F

Q36421137-575E0212-1935-4497-9C64-9C02A5F89396

P304

Q36421137-D576A517-DBF7-4CCC-874A-6B2553E090D8

P31

Q36421137-56F25FFB-9113-4139-B036-98071FE77043

P356

Q36421137-2B2A296E-CC7F-4D79-8C70-D9025DB27F5C

P407

Q36421137-DDA171AE-E993-4760-95B3-1086937C6C91

P433

Q36421137-DDA329F4-82DE-4947-B563-7D8DB27E978D

P478

Q36421137-189762C5-7599-427A-A6A2-A43D7EE1E130

P50

Q36421137-28D14474-9FBF-41C5-8943-3EB68EB780BC

Q36421137-99974899-AE7B-405A-A8BE-1830F0409593

P577

Q36421137-CF29947A-A7C7-42AB-9BE0-D93585055BE2

P5875

Q36421137-628B0687-1425-4211-9956-7918797A001F

P698

Q36421137-FD64045E-A141-4CC2-9AC4-40A5BB27C02F

P932

Q36421137-3843FBDD-B046-4CB9-BACD-B9367C697FBA

P356

P1433

Molecular and Cellular Biology

P1476

Regulation of Notch signaling ...... sion of S3 cleavage of Notch-1

@en

P2093

Akiko Ikuta

http://www.w3.org/2001/XMLSchema#string

Akio Fukumori

http://www.w3.org/2001/XMLSchema#string

Jingwei Jiang

http://www.w3.org/2001/XMLSchema#string

Kanta Yanagida

http://www.w3.org/2001/XMLSchema#string

Kouhei Nishitomi

http://www.w3.org/2001/XMLSchema#string

Kouzin Kamino

http://www.w3.org/2001/XMLSchema#string

Masatoshi Takeda

http://www.w3.org/2001/XMLSchema#string

Naohiko Matsumoto

http://www.w3.org/2001/XMLSchema#string

Naohiro Itoh

http://www.w3.org/2001/XMLSchema#string

Shigeru Chiba

http://www.w3.org/2001/XMLSchema#string

P2860

Notch signaling: cell fate control and signal integration in development

Alzheimer's disease: genes, proteins, and therapy

Notch signaling: from the outside in

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

In vivo half-life of a protein is a function of its amino-terminal residue

Signalling downstream of activated mammalian Notch

P304

165-176

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.00863-07

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

28

http://www.w3.org/2001/XMLSchema#string

P50

Masayasu Okochi

Ryota Hashimoto

P577

2007-10-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5878158

http://www.w3.org/2001/XMLSchema#string

P698

17967888

http://www.w3.org/2001/XMLSchema#string

P932

2223315

http://www.w3.org/2001/XMLSchema#string