Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.
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Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine groupTopoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitorsLocalization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cellsThe topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cellsCRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo.Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition.Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.Base mutation analysis of topoisomerase II-idarubicin-DNA ternary complex formation. Evidence for enzyme subunit cooperativity in DNA cleavage.Quantitative immunofluorescence and immunoelectron microscopy of the topoisomerase II alpha associated with nuclear matrices from wild-type and drug-resistant chinese hamster ovary cell lines.Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatin.Characterization of an etoposide-resistant human K562 cell line, K/eto.Transfection of human topoisomerase II alpha into etoposide-resistant cells: transient increase in sensitivity followed by down-regulation of the endogenous geneCell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II.A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
P2860
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P2860
Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Purification and characterizat ...... inese hamster ovary cell line.
@en
Purification and characterizat ...... inese hamster ovary cell line.
@nl
type
label
Purification and characterizat ...... inese hamster ovary cell line.
@en
Purification and characterizat ...... inese hamster ovary cell line.
@nl
prefLabel
Purification and characterizat ...... inese hamster ovary cell line.
@en
Purification and characterizat ...... inese hamster ovary cell line.
@nl
P2093
P356
P1433
P1476
Purification and characterizat ...... inese hamster ovary cell line.
@en
P2093
P304
P356
10.1021/BI00439A051
P407
P577
1989-06-01T00:00:00Z