Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
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A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiencyProgesterone receptor membrane component 1 inhibits the activity of drug-metabolizing cytochromes P450 and binds to cytochrome P450 reductaseA cytochrome b5 is required for full activity of flavonoid 3', 5'-hydroxylase, a cytochrome P450 involved in the formation of blue flower colorsThe molecular biology, biochemistry, and physiology of human steroidogenesis and its disordersRecollection of the early years of the research on cytochrome P450Structure and mechanism of the complex between cytochrome P4503A4 and ritonavirEffect of Cytochrome b5 Content on the Activity of Polymorphic CYP1A2, 2B6, and 2E1 in Human Liver MicrosomesCYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysisRedox potential control by drug binding to cytochrome P450 3A4Interactions between cytochrome P450 and cytochrome b5.Role of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicityKinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11Experimental approaches to evaluate activities of cytochromes P450 3AAllosteric phenomena in cytochrome P450-catalyzed monooxygenations.Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer.Bioelectronic delivery of electrons to cytochrome P450 enzymesCytochrome P450: what have we learned and what are the future issues?Cytochromes P450--a family of proteins and scientists-understanding their relationships.Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).Control of electrochemical and ferryloxy formation kinetics of cyt P450s in polyion films by heme iron spin state and secondary structureThe action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b5 in Leydig Cells.Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activityInfluence of protein-protein interactions on the cellular localization of cytochrome P450.NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.Substrate binding to cytochromes P450.Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice.Structural diversity of cytochrome P450 enzyme system.Biological membranes are nanostructures that require internal heat and imaginary temperature as new, unique physiological parameters related to biological catalysts.Formation of P450 · P450 complexes and their effect on P450 functionIdentification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis.The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes.The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.Two surfaces of cytochrome b5 with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries.Knockdown of several components of cytochrome P450 enzyme systems by RNA interference enhances the susceptibility of Helicoverpa armigera to fenvalerate.Reduction of aromatic and heterocyclic aromatic N-hydroxylamines by human cytochrome P450 2S1.Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.
P2860
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P2860
Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@en
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@nl
type
label
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@en
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@nl
prefLabel
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@en
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@nl
P2093
P2860
P356
P1476
Lack of electron transfer from ...... tudies with apo-cytochrome b5.
@en
P2093
Guengerich FP
Johnson WW
P2860
P304
27438-27444
P356
10.1074/JBC.271.44.27438
P407
P577
1996-11-01T00:00:00Z