Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.
about
Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell lineCasein kinase II catalyzes a mitotic phosphorylation on threonine 1342 of human DNA topoisomerase IIalpha, which is recognized by the 3F3/2 phosphoepitope antibody.Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to facilitate virion productionCasein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.Method for quantifying expression of functionally active topoisomerase II in patients with leukaemia.DNA topoisomerase II and its growing repertoire of biological functions.Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549.Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events.Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIMitotic phosphorylation: breaking the balance of power by a tactical retreat.Eukaryotic DNA topoisomerase II beta.Chromosome Formation During Fertilization in Eggs of the Teleost Oryzias latipes.Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain.TOP2B: The First Thirty Years
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P2860
Human topoisomerase II alpha is phosphorylated in a cell-cycle phase-dependent manner by a proline-directed kinase.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
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1995年學術文章
@zh-hant
name
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@en
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@nl
type
label
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@en
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@nl
prefLabel
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@en
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@nl
P2860
P1433
P1476
Human topoisomerase II alpha i ...... by a proline-directed kinase.
@en
P2093
I D Hickson
P2860
P304
P356
10.1111/J.1432-1033.1995.TB20723.X
P407
P577
1995-07-01T00:00:00Z