A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process
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The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structuresDiverged nuclear localization of Werner helicase in human and mouse cellsp53 Modulates the exonuclease activity of Werner syndrome proteinIdentification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Asymmetry of DNA replication fork progression in Werner's syndromeThe Bloom's syndrome gene product promotes branch migration of holliday junctionsDNA Damage: A Main Determinant of Vascular AgingGenetics of primary ovarian insufficiency: new developments and opportunitiesMetabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceCancer predisposition caused by elevated mitotic recombination in Bloom miceFunctional interaction between Ku and the werner syndrome protein in DNA end processingA novel protein interacts with the Werner's syndrome gene product physically and functionallyEpigenetic inactivation of the premature aging Werner syndrome gene in human cancerAccelerating aging by mouse reverse genetics: a rational approach to understanding longevityThe impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δCytogerontology since 1881: a reappraisal of August Weismann and a review of modern progressCovalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1WRN mutations in Werner syndromeWerner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex.A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.Werner syndrome gene variants in human sarcomasWhat geriatricians should know about the Werner syndrome.A case of Werner's syndrome associated with osteosarcoma.Physical and functional interaction between p53 and the Werner's syndrome protein.Functional interaction between the Werner Syndrome protein and DNA polymerase deltaRegulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.G-quadruplex nucleic acids and human diseaseLessons from human progeroid syndromes.WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.Progeria syndromes and ageing: what is the connection?Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditionsWRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Genomic instability in head and neck cancer patients.Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.MHF1 plays Fanconi anaemia complementation group M protein (FANCM)-dependent and FANCM-independent roles in DNA repair and homologous recombination in plants.Epigenetic gene silencing in cancer: the DNA hypermethylome.Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A
P2860
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P2860
A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process
description
article
@en
im Mai 1966 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 1966
@uk
ലേഖനം
@ml
name
A Review of its Symptomatology ...... p to the Natural Aging Process
@en
A Review of its Symptomatology ...... p to the Natural Aging Process
@nl
type
label
A Review of its Symptomatology ...... p to the Natural Aging Process
@en
A Review of its Symptomatology ...... p to the Natural Aging Process
@nl
prefLabel
A Review of its Symptomatology ...... p to the Natural Aging Process
@en
A Review of its Symptomatology ...... p to the Natural Aging Process
@nl
P2093
P1433
P1476
A Review of its Symptomatology ...... p to the Natural Aging Process
@en
P2093
AMELIA L. SCHULTZ
ARNO G. MOTULSKYS
CHARLES J. EPSTKIN
GEORGE M. MARTIN
P304
P356
10.1097/00005792-196605000-00001
P407
P577
1966-05-01T00:00:00Z