about
DNA nucleotide excision repair-dependent signaling to checkpoint activationRibonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repairThe novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.Phosphorylation of the budding yeast 9-1-1 complex is required for Dpb11 function in the full activation of the UV-induced DNA damage checkpoint.DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae.Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase εThe DNA replication checkpoint response stabilizes stalled replication forksNER and DDR: classical music with new instruments.Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint.Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activityMutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28.A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage.Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instabilityRNase H and postreplication repair protect cells from ribonucleotides incorporated in DNAHedgehogs, humans and high-school science. The benefits of involving high-school students in university research.Checkpoint mechanisms at the intersection between DNA damage and repair.Mind the gap: keeping UV lesions in check.Bimodal regulation of p21(waf1) protein as function of DNA damage levels.A role for DNA primase in coupling DNA replication to DNA damage response.To trim or not to trim: progression and control of DSB end resectionEvidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.DNA damage checkpoint in budding yeast.Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.One-step high-throughput assay for quantitative detection of beta-galactosidase activity in intact gram-negative bacteria, yeast, and mammalian cells.Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1.Genetic mapping of the Saccharomyces cerevisiae DNA polymerase I gene and characterization of a pol1 temperature-sensitive mutant altered in DNA primase-polymerase complex stability.Yeast haspin kinase regulates polarity cues necessary for mitotic spindle positioning and is required to tolerate mitotic arrest.Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair.Sometimes size does matter.DNA synthesis catalyzed in vitro by yeast extracts using A 2 μm DNA containing plasmid as template for enzymatic DNA synthesis.Positive cis-acting regulatory sequences mediate proper control of POL1 transcription in Saccharomyces cerevisiae.Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.Exo1 competes with repair synthesis, converts NER intermediates to long ssDNA gaps, and promotes checkpoint activation.Polypeptide structure of human terminal transferase
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Paolo Plevani
@ast
Paolo Plevani
@en
Paolo Plevani
@es
Paolo Plevani
@nl
type
label
Paolo Plevani
@ast
Paolo Plevani
@en
Paolo Plevani
@es
Paolo Plevani
@nl
prefLabel
Paolo Plevani
@ast
Paolo Plevani
@en
Paolo Plevani
@es
Paolo Plevani
@nl
P106
P1153
7004005442
P31
P496
0000-0003-1869-2626