Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing - Wikidata - awgldk - TriplyDB

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

http://www.wikidata.org/entity/Q59086518

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Shortened telomere length is associated with increased risk of cancer: a meta-analysis Telomerase inhibitor PinX1 provides a link between TRF1 and telomerase to prevent telomere elongation Connecting the Dots: From DNA Damage and Repair to Aging Adult stem cell and mesenchymal progenitor theories of aging.Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells The role of telomeres and telomerase in stem cell aging Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training.Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells Stem cell aging: mechanisms, regulators and therapeutic opportunities.The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance Progeroid syndromes: models for stem cell aging?Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation.Telomerase RNA levels limit the telomere length equilibrium.Regulation of senescence in cancer and aging.Involvement of the INK4a/Arf gene locus in senescence.Telomerase as a novel and potentially selective target for cancer chemotherapy.Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.DNA damage checkpoint kinase Chk2 triggers replicative senescence.Current status of efforts to measure and modulate the biological rate of aging.Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms Global heterochromatin loss: a unifying theory of aging?ATM regulates the length of individual telomere tracts in Arabidopsis Molecular basis of ataxia telangiectasia and related diseases.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs H2AX regulates meiotic telomere clustering.ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

http://www.wikidata.org/entity/Q59086518

description

article publié dans la revue scientifique Nature

@fr

scientific article published in Nature

@en

wetenschappelijk artikel

@nl

наукова стаття, опублікована в Nature в січні 2003

@uk

name

Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

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Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

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type

label

Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

@en

Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

@nl

prefLabel

Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

@en

Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

@nl

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Telomere dysfunction and Atm d ...... ostasis and accelerates ageing

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Daniel R Carrasco

http://www.w3.org/2001/XMLSchema#string

Frederick W Alt

http://www.w3.org/2001/XMLSchema#string

Jayant Menon

http://www.w3.org/2001/XMLSchema#string

Richard S Maser

http://www.w3.org/2001/XMLSchema#string

Robert M Bachoo

http://www.w3.org/2001/XMLSchema#string

Ronald A DePinho

http://www.w3.org/2001/XMLSchema#string

Yansong Gu

http://www.w3.org/2001/XMLSchema#string

P2860

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

The many substrates and functions of ATM

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

Essential role of mouse telomerase in highly proliferative organs

p53 mutant mice that display early ageing-associated phenotypes

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.

ATM function and telomere stability.

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scholarly article

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10.1038/NATURE01385

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6923

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421

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2003-01-22T00:00:00Z

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1004995747

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12540856

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