The spectrum of SWI/SNF mutations, ubiquitous in human cancers
about
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutationMammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsInterplay between Transcription Factors and the Epigenome: Insight from the Role of RUNX1 in LeukemiaFrom human genome to cancer genome: the first decadeATP-dependent chromatin remodeling complexes as novel targets for cancer therapyIt takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brainCoordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expressionGenetic alterations in hepatocellular carcinoma: An updateThe Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear StructureGenome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF ComplexesTargeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancerThe mutational landscape of chromatin regulatory factors across 4,623 tumor samples.The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell ProliferationEstablishment and characterization of a novel ovarian clear cell carcinoma cell line, TU-OC-2, with loss of ARID1A expression.From neural development to cognition: unexpected roles for chromatin.A potentially functional variant of ARID1B interacts with physical activity in association with risk of hepatocellular carcinoma.Chromatin-regulating proteins as targets for cancer therapy.SWI/SNF chromatin remodeling enzymes in melanocyte differentiation and melanoma.Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cellsLoss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibitionRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.Detecting protein complexes in protein interaction networks using a ranking algorithm with a refined merging procedure.Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups.Expression inactivation of SMARCA4 by microRNAs in lung tumorsFunctional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.Regulating the chromatin landscape: structural and mechanistic perspectives.SWI/SNF complexes are required for full activation of the DNA-damage response.Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type.EZH2 as a potential target in cancer therapy.Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.Histone methylases as novel drug targets: developing inhibitors of EZH2.Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cellsPan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotypeChromatin Remodelers: From Function to Dysfunction.DNA methylation subgroups in melanoma are associated with proliferative and immunological processesHepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia MaintenancePBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell CarcinomaEpigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition.Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma
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P2860
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
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2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@ast
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en-gb
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@nl
type
label
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@ast
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en-gb
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@nl
altLabel
The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers
@en
prefLabel
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@ast
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@en-gb
The spectrum of SWI/SNF mutations, ubiquitous in human cancers
@nl
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The spectrum of SWI/SNF mutations, ubiquitous in human cancers
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A Hunter Shain
Jonathan R Pollack
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10.1371/JOURNAL.PONE.0055119
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P577
2013-01-01T00:00:00Z