negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

Item
http://www.wikidata.org/entity/Q14860027
Sonic hedgehogParkin RBR E3 ubiquitin protein ligaseEarly growth response 1GLI-Kruppel family member GLI1GLI-Kruppel family member GLI3SclerostinBone morphogenetic protein 2EmerinTranscription factor 7 like 2Transcription factor 7 like 2, T cell specific, HMG boxHistone deacetylase 1Wingless-type MMTV integration site family, member 4Mitogen-activated protein kinase 14Proteasome 26S subunit, non-ATPase 9SEM1, 26S proteasome complex subunitProteasome inhibitor subunit 1Forkhead box O3Chromodomain helicase DNA binding protein 8Forkhead box O1Glypican 3Proteasome 20S subunit alpha 1Rap guanine nucleotide exchange factor 1Large tumor suppressor kinase 2APC regulator of WNT signaling pathway 2DAB2 interacting proteinProteasome 26S subunit, ATPase 5Proteasome 20S subunit beta 4TLE family member 1, transcriptional corepressorCasein kinase 1 alpha 1Casein kinase 1 alpha 1 likeProteasome 26S subunit, non-ATPase 10Cadherin 2SRY-box transcription factor 17Proteasome 26S subunit, non-ATPase 14Gremlin 1, DAN family BMP antagonistSerine/threonine kinase 11WW domain containing transcription regulator 1Axin 1Dishevelled segment polarity protein 2Cullin 3
P682
Identification of a brain-specific APC homologue, APCL, and its interaction with beta-cateninIdentification of APC2, a homologue of the adenomatous polyposis coli tumour suppressorInteraction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signalingMutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signallingSecond cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelledEpigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instabilityIdentification of TMEM131L as a novel regulator of thymocyte proliferation in humansActivation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalingSecreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cellsIdentification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancerPeutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signalingInhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned ratsHistone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathwayNoncanonical Wnt11 inhibits hepatocellular carcinoma cell proliferation and migrationThe inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusInhibitory Gli3 activity negatively regulates Wnt/beta-catenin signalingAmer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterningBone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator functionStructural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membraneLoss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of DvlSOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorSFRP1 suppressed hepatoma cells growth through Wnt canonical signaling pathwayMutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tractStructure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist functionLRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndromePrickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancerThe human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascadeSuppressing Wnt signaling by the hedgehog pathway through sFRP-1Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitroThe Hippo pathway regulates Wnt/beta-catenin signalingRepressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancerMutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcriptionUp-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumorsGroucho binds two conserved regions of LEF-1 for HDAC-dependent repressionSkeletal overexpression of gremlin impairs bone formation and causes osteopeniaNegative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 geneLoss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasiaSOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic developmentCHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes
P921
Q14860215-B5258F3A-98AD-49D9-A49A-9E0A56A6CAACQ14864264-26A54022-850E-4034-8922-1F6FBDBB804EQ14864827-F1245E6A-3DD8-4658-A8C1-F5E0DB755586Q14886456-8A901116-EEDF-4EC3-917F-5991EF27F5EDQ14886933-98E56F88-C9C0-4930-9335-AD76837B2E6DQ14887297-CFF33E15-33D6-49F2-89DC-AACF09B1B884Q14903156-33A94BA2-C367-4B6C-9BE0-EB80B53CC41EQ14906927-5A3CFF6F-F5F3-4D2F-B095-507149EF4B38Q14906927-B48149C6-EB73-4B83-B2EC-4AE7EC947D67Q14913880-57DDE202-3FC9-4458-A14C-31B176A42492Q14913903-D3BAF029-14A2-484B-A185-A611487859A2Q14914426-884903FD-1E5C-47F4-8E22-F30B598BA5BCQ14914426-F840FBED-BE3B-4774-93F6-93368C65CEE5Q15321888-2D3AA26E-530B-4329-9766-DDCF0B2EC3BCQ15321888-4A4D7DE2-E3EF-4B44-9728-EACA6066A41FQ15326939-355A16EE-CD5B-48C8-9FC3-071A1E710175Q21100313-B02DDD71-4A16-4472-A236-E15398F4B9C3Q21100461-90C2DD1B-E6D5-4DE4-BB69-45C096052047Q21101367-692E300C-6FED-4CFA-9F08-26C8EADADC8DQ21101484-801718D7-4B91-4070-B158-3926D867A722Q21102093-14552F53-5D6B-4EBD-9AB1-081E83D041DCQ21102093-B31271DC-DB9F-4313-A27C-5B7EE93C16DFQ21102210-384F0A58-8001-4A83-9C7A-B0B2B34722D2Q21103196-474B16F7-DBB9-4F8D-9AD3-092E159AAA4FQ21104752-71CB0E90-2C5D-4A3D-84BC-605A955204A5Q21104809-E0C350BC-4F27-461C-8D24-B2F40FCF2D33Q21105103-1B47FAD5-5607-4D34-88E4-8437EEF0F403Q21105103-EDD7A681-281F-4056-A21E-3857081BFEA0Q21105220-52EEEAB4-79F1-49B7-9F50-13DDBB8B5B56Q21105220-D9BCB197-AE6C-4B66-9826-C59C3ECBBB61Q21105736-2919CD08-DE83-4D67-AF88-5962AB8307B3Q21105835-75411A53-61D0-44E4-9A10-F74578F14D33Q21107489-322F54B0-CF47-4738-92FC-070583D82016Q21107568-7DCDFA80-9FF3-4DCC-B0E3-C1BBE63ED14DQ21107836-40DEA561-5AC4-4F30-A145-D1B4A4D61A0FQ21107836-93473BF9-38AC-477C-B3DB-9FE88C612857Q21107848-023C9D4B-4A27-4521-9EC5-3CD196C0A7AEQ21107941-246BC6B2-B4CD-41D0-A926-A3990EDF1B0DQ21108319-3191D0AA-6F5C-411A-AAD5-B6DC60234B33Q21108516-B6A91F10-C9A8-4854-B2F3-1B5F875B9A8E
P682
Q22008030-0A645DA8-2BD3-45C1-B1A6-6489E46DF1F0Q22008756-6B69F8AB-F55E-40DA-BD63-3C42E11DB141Q22009909-332A3999-84C5-4D04-828D-56107AB34EFCQ24290355-2D9AB8B8-DBC0-41C1-AAAD-A70BEAAD6BE5Q24292013-AF99B0E0-345E-49B5-86E4-B156809DCAA0Q24292772-16FEDECD-99C2-44DF-BE32-9CC70CA273CFQ24293426-890F6EE2-49FC-4E4A-8C90-6EA67B9F77F2Q24293496-1EF844A2-C13B-4BB5-8924-DC20F3080A24Q24294749-EC410D0E-E079-4334-9E8C-DAF8DCA4E22EQ24294957-6E8DB3C8-8826-4B7E-BCA5-6666136BA43EQ24296680-7C9B10ED-C7D3-4CEC-884E-09DD0F5BCAA9Q24296942-64234251-EF89-415B-82A5-4F35065D396CQ24297336-DE4569AA-25AE-4157-8924-AEB82E13B734Q24297486-2742FBF1-C2A8-4B09-916A-D3B0E4C8F1AFQ24297804-3537B02E-83C9-4FCA-B927-A9A293DDE944Q24298606-B301BD2C-9335-401E-9D04-22FB596ADD4BQ24298675-574A12C3-3704-41E3-B769-2088E679D37DQ24299076-6644C14C-121A-495A-8807-425176906965Q24299895-FDB4D166-A71D-42C9-92F8-9013071C50C1Q24300632-DF381028-5351-432B-8686-C3222ADCB0B8Q24302528-5D8D07DB-8EF0-4462-89B5-8AB30FA4A728Q24303393-CCD77924-3EDC-4310-AFEA-0D25142369C0Q24303537-D63A2B26-18BB-4A95-A003-AD34FB0C8AA2Q24304067-83BDD512-2154-4F41-9505-BD24F7ECCD45Q24304386-5F4A446B-328F-4C91-B332-6E002ACC1086Q24306285-6DF3BB80-5032-430A-9ECD-4A853998D265Q24306388-A27FF662-4DFC-4736-8CD0-46929C0732CDQ24306497-BA7C5586-98DB-41A4-B971-79C2AA733FC8Q24306581-5612B620-FDAC-459E-9624-77DDF1C366A5Q24307058-CF4BD572-9AD9-40E4-A32F-C6E44A6DED95Q24307606-CFD34E4A-E381-4EFA-B91D-8AF92EE7338CQ24307736-505C194C-D7D5-4A4C-B196-DB6501A536BDQ24308753-19CC5402-0D56-4391-963A-89D73267C3FBQ24309604-5FE601D0-2F75-46D9-91E7-8A837B7BADCAQ24312550-6ABE93DB-5885-438C-A07E-E3A2B46EA988Q24314447-6571F386-24C5-4216-9166-DC54F22B74C9Q24314566-14DBA7BB-BD2E-4EF8-9EF7-B3C4B22A8D6AQ24315070-97F57A06-8D4B-4865-B19B-B4460F34B1D4Q24315523-F52F9BCC-391F-4DF9-A7AD-016289680C41Q24315938-6320D5A9-0A9E-4098-94D5-1376637B474C
P921

negative regulation of canonical Wnt signaling pathway

Item
http://www.wikidata.org/entity/Q14860027
description
Any process that decreases the ...... ace of the target cell, follow
@en
biologisch proces
@nl
name
negative regulation of canonical Wnt signaling pathway
@en
type
label
negative regulation of canonical Wnt signaling pathway
@en
altLabel
GO:0090090
@en
negative regulation of Wnt receptor signaling pathway through beta-catenin
@en
negative regulation of canonical Wnt receptor signaling pathway
@en
negative regulation of canonical Wnt receptor signalling pathway
@en
negative regulation of canonical Wnt-activated signaling pathway
@en
prefLabel
negative regulation of canonical Wnt signaling pathway
@en
P128
P279
P2888
P31
P686
P128
P279
P2888
P31
P686