Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
about
Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activationThe neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease miceA mutation in APP protects against Alzheimer’s disease and age-related cognitive declinePAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinIdentification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavageGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionSorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processingFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingThe Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motifBiological markers of amyloid beta-related mechanisms in Alzheimer's diseaseAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsBACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinThe amyloid precursor protein: beyond amyloidPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsAmyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET ImagingTDP-43: a new player on the AD field?The role of APP and BACE1 trafficking in APP processing and amyloid-β generationTrafficking regulation of proteins in Alzheimer's diseaseInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseToward the structure of presenilin/γ-secretase and presenilin homologsGeneral anesthetics and β-amyloid proteinComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretaseStructure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolutionCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseFlexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsAPP processing in Alzheimer's diseaseProteomic Substrate Identification for Membrane Proteases in the BrainPMEL Amyloid Fibril Formation: The Bright Steps of PigmentationThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseGenetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinProteolytic processing of Alzheimer's β-amyloid precursor proteinBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseTrafficking and proteolytic processing of APPReticulon family members modulate BACE1 activity and amyloid-beta peptide generationCysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's diseaseBACE1 expression and activity: relevance in Alzheimer's disease
P2860
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P2860
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@ast
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en-gb
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@nl
type
label
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@ast
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en-gb
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@nl
prefLabel
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@ast
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en-gb
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@nl
P2093
P921
P3181
P356
P1433
P1476
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
@en
P2093
A G Tomasselli
A M Pauley
D B Carter
J R Brashier
L A Parodi
M E Gurney
P2888
P3181
P356
10.1038/990107
P407
P577
1999-12-02T00:00:00Z
P6179
1020200049