DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. - Test2 - elhamkhani - TriplyDB

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

http://www.wikidata.org/entity/Q24540261

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Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity Turning the RING domain protein MdmX into an active ubiquitin-protein ligase MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation MDMX regulation of p53 response to ribosomal stress An essential function of the extreme C-terminus of MDM2 can be provided by MDMX DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage MDM4 (MDMX) and its Transcript Variants.ATM activates p53 by regulating MDM2 oligomerization and E3 processivity Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.MDM2 oligomers: antagonizers of the guardian of the genome.Regulation of p53-MDMX interaction by casein kinase 1 alpha.Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage SHP2E76K mutant promotes lung tumorigenesis in transgenic mice MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame HdmX overexpression inhibits oncogene induced cellular senescence.Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability MDM2 promotes ubiquitination and degradation of MDMX Abnormal MDMX degradation in tumor cells due to ARF deficiency Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.Regulation of MDMX expression by mitogenic signaling.Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.Functions of MDMX in the modulation of the p53-response.Mdm2 and MdmX partner to regulate p53.c-Abl phosphorylates Hdmx and regulates its interaction with p53.MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.Critical role for a central part of Mdm2 in the ubiquitylation of p53.Full-length hdmX transcripts decrease following genotoxic stress.Telomere attrition induces a DNA double-strand break damage signal that reactivates p53 transcription in HTLV-I leukemic cells.MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

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P2860

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

http://www.wikidata.org/entity/Q24540261

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

DNA damage induces MDMX nuclea ...... nt and -independent mechanisms

@nl

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@ast

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@en

type

label

DNA damage induces MDMX nuclea ...... nt and -independent mechanisms

@nl

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@ast

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@en

prefLabel

DNA damage induces MDMX nuclea ...... nt and -independent mechanisms

@nl

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@ast

DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@en

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MCB.22.21.7562-7571.2002

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Molecular and Cellular Biology

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DNA damage induces MDMX nuclea ...... t and -independent mechanisms.

@en

P2093

Changgong Li

http://www.w3.org/2001/XMLSchema#string

Jiandong Chen

http://www.w3.org/2001/XMLSchema#string

Lihong Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Identification of a cryptic nucleolar-localization signal in MDM2

MDMX: a novel p53-binding protein with some functional properties of MDM2

MDM2 interacts with MDMX through their RING finger domains

MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7562-7571

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scholarly article

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10.1128/MCB.22.21.7562-7571.2002

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21

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22

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11090070

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12370303

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135668

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