Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
about
Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plantsBubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.The ubiquitin proteasome system in neuropathologyIdentification of Rab11 as a small GTPase binding protein for the Evi5 oncogeneInsights into APC/C: from cellular function to diseases and therapeuticsFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisModulation of cell cycle control during oocyte-to-embryo transitionsAtomic structure of the APC/C and its mechanism of protein ubiquitination.Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit.High-throughput generation of tagged stable cell lines for proteomic analysis.The polyglutamine-expanded androgen receptor responsible for spinal and bulbar muscular atrophy inhibits the APC/C(Cdh1) ubiquitin ligase complex.The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationInsights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 ComplexElectron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdownCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationPseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1.Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation.Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complexModulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.Getting to S: CDK functions and targets on the path to cell-cycle commitmentThe DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosomeMad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpointMouse Emi2 as a distinctive regulatory hub in second meiotic metaphaseEmi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/CInsights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons.The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome.Arabidopsis COPPER MODIFIED RESISTANCE1/PATRONUS1 is essential for growth adaptation to stress and required for mitotic onset control.The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sitesRegulation of APC/C activators in mitosis and meiosis.Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactionsThe role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage.Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division.Roles of F-box proteins in cancerRING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexMolecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent functionMad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.
P2860
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P2860
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@ast
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en-gb
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@nl
type
label
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@ast
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en-gb
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@nl
prefLabel
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@ast
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en-gb
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Emi1 stably binds and inhibits ...... as a pseudosubstrate inhibitor
@en
P2093
Alex Loktev
Julie J Miller
Matthew K Summers
Peter K Jackson
P2860
P304
P3181
P356
10.1101/GAD.1454006
P407
P577
2006-09-01T00:00:00Z