about
sameAs
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesisHERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomesTRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomesE2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpointDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteinsCentrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseRNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteinsUbiquitin-activating enzyme UBA1 is required for cellular response to DNA damageHuman RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaksHuman Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activitiesCDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombinationPhosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localizationNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionHuman CtIP promotes DNA end resectionUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationLoss of Geminin induces rereplication in the presence of functional p53The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorDistinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitorsPathways governing G1/S transition and their response to DNA damageDeregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregationRepression of p15INK4b expression by Myc through association with Miz-1Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaksAberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing geneDestruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stressRegulation of replication fork progression through histone supply and demandATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damageCyclin D1 is a nuclear protein required for cell cycle progression in G1Human Asf1 regulates the flow of S phase histones during replicational stressDNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumoursAbnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancerPhosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block.Rapid destruction of human Cdc25A in response to DNA damageRegulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stabilityMammalian G1- and S-phase checkpoints in response to DNA damageOncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsLiquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).
P50
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P50
description
Tsjechisch onderzoeker
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hulumtues
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investigador checo
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investigador checu
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researcher
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taighdeoir
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tschechischer Forscher
@de
հետազոտող
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name
Jiří Lukáš
@ast
Jiří Lukáš
@cs
Jiří Lukáš
@da
Jiří Lukáš
@de
Jiří Lukáš
@en
Jiří Lukáš
@es
Jiří Lukáš
@fo
Jiří Lukáš
@fr
Jiří Lukáš
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Jiří Lukáš
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type
label
Jiří Lukáš
@ast
Jiří Lukáš
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Jiří Lukáš
@da
Jiří Lukáš
@de
Jiří Lukáš
@en
Jiří Lukáš
@es
Jiří Lukáš
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Jiří Lukáš
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Jiří Lukáš
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Jiří Lukáš
@is
altLabel
Jiri Lukas
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prefLabel
Jiří Lukáš
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Jiří Lukáš
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Jiří Lukáš
@da
Jiří Lukáš
@de
Jiří Lukáš
@en
Jiří Lukáš
@es
Jiří Lukáš
@fo
Jiří Lukáš
@fr
Jiří Lukáš
@ga
Jiří Lukáš
@is
P106
P21
P31
P496
0000-0001-9087-506X