Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells - Test2 - elhamkhani - TriplyDB

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

http://www.wikidata.org/entity/Q24300095

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Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Modeling Alzheimer's Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns The Progress of Induced Pluripotent Stem Cells as Models of Parkinson's Disease Induced pluripotent stem cells for modeling neurological disorders Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases Using iPS Cells toward the Understanding of Parkinson's Disease Mitochondrial dynamism and heart disease: changing shape and shaping change Patient-specific induced pluripotent stem cells in neurological disease modeling: the importance of nonhuman primate models Cellular models to investigate biochemical pathways in Parkinson's disease iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery Human pluripotent stem cells for modelling human liver diseases and cell therapy Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency The pathways of mitophagy for quality control and clearance of mitochondria Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery Physiological characterisation of human iPS-derived dopaminergic neurons Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: Focus on Parkinson's disease Induced pluripotent stem cell potential in medicine, specifically focused on reproductive medicine Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1 Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling High-throughput screening in primary neurons Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.Investigating human disease using stem cell models.Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells.Modeling human neurological disorders with induced pluripotent stem cells.

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P2860

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

http://www.wikidata.org/entity/Q24300095

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

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name

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

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Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

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Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

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Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@nl

type

label

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@ast

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@en

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

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Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@nl

prefLabel

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@ast

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@en

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@en-gb

Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

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JNEUROSCI.4441-10.2011

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Journal of Neuroscience

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Mitochondrial Parkin recruitme ...... induced pluripotent stem cells

@en

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Dimitri Krainc

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Filip Simunovic

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Hyun Jeong

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John Graziotto

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Philip Seibler

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells

PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia

Disease-specific induced pluripotent stem cells

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5970-6

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10.1523/JNEUROSCI.4441-10.2011

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16

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31

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Christine Klein

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51065699

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21508222

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regulation of protein targeting to mitochondrion

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3091622

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