Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
about
Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activityStructural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loopsPivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetateDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolSubunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complexCrystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implicationsComparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.Crystal Structure of Pyruvate Dehydrogenase Phosphatase 1 and its Functional ImplicationsStructural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding PocketYIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex.Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen speciesAllosteric coupling in pyruvate dehydrogenase kinase 2Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosisA new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.The pyruvate dehydrogenase complexes: structure-based function and regulation.Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases.Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonanceDifferential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetateDirect and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy.Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cellsA structural perspective on enzymes activated by monovalent cations.Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic OptimumRole of Na+ and K+ in enzyme function.Intrinsic negative feedback governs activation surge in two-component regulatory systems.Dichloroacetate potentiates tamoxifen-induced cell death in breast cancer cells via downregulation of the epidermal growth factor receptor.Molecular Mechanisms of Enzyme Activation by Monovalent Cations.Global view of cognate kinase activation by the human pyruvate dehydrogenase complex.The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activity.Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.Expression, purification and molecular modeling of another HdrC from Acidithiobacillus ferrooxidans which binds only one [4Fe-4S] cluster.Comparative homology modeling of pyruvate dehydrogenase kinase isozymes from Xenopus tropicalis reveals structural basis for their subfunctionalization.Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.Regarding the torsional flexibility of the dihydrolipoic acid's pharmacophore: 1,3-propanedithiol.Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.
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P2860
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@ast
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en-gb
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@nl
type
label
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@ast
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en-gb
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@nl
prefLabel
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@ast
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en-gb
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@nl
P2093
P2860
P921
P356
P1433
P1476
Crystal structure of pyruvate ...... pyruvate dehydrogenase complex
@en
P2093
David T Chuang
Jacinta L Chuang
Masato Kato
Shih-Chia Tso
P2860
P304
P356
10.1038/SJ.EMBOJ.7600663
P407
P577
2005-04-28T00:00:00Z