Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase
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Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complexCrystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complexPyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activityPivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetateDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolInteraction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complexSubunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complexCrystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implicationsStructural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding PocketFacilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferaseRecent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKsThe C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinaseInactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen speciesAllosteric coupling in pyruvate dehydrogenase kinase 2The pyruvate dehydrogenase complexes: structure-based function and regulation.Regulation of pyruvate metabolism and human diseaseStructural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonanceEssential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndromePyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders.Histidine kinases from bacteria to humans.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Detection of pyruvate dehydrogenase E1 alpha-subunit deficiencies in females by immunohistochemical demonstration of mosaicism in cultured fibroblasts.Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activity.The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activity.Amino acid residues responsible for the recognition of dichloroacetate by pyruvate dehydrogenase kinase 2.Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.Histidine mutagenesis of Arabidopsis thaliana pyruvate dehydrogenase kinase.R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.Comparative homology modeling of pyruvate dehydrogenase kinase isozymes from Xenopus tropicalis reveals structural basis for their subfunctionalization.Ligand-induced effects on pyruvate dehydrogenase kinase isoform 2.
P2860
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P2860
Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@ast
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@en
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@nl
type
label
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@ast
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@en
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@nl
altLabel
Structure of Pyruvate Dehydrog ...... RN FOR A SERINE PROTEIN KINASE
@en
prefLabel
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@ast
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@en
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@nl
P2093
P2860
P921
P356
P1476
Structure of pyruvate dehydrog ...... rn for a serine protein kinase
@en
P2093
C N Steussy
J A Hamilton
M M Bowker-Kinley
R A Harris
P2860
P304
P356
10.1074/JBC.M104285200
P407
P577
2001-10-05T00:00:00Z