Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 - Test2 - elhamkhani - TriplyDB

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells.Anticancer agents that counteract tumor glycolysis.Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases.FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival.Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.Global view of cognate kinase activation by the human pyruvate dehydrogenase complex.Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.

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P2860

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

http://www.wikidata.org/entity/Q27673456

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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type

label

Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

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Acta Crystallographica Section D: Biological Crystallography

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Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4

@en

P2093

Alexander Tokmakov

http://www.w3.org/2001/XMLSchema#string

Ikuya Shiromizu

http://www.w3.org/2001/XMLSchema#string

Masaki Kawamoto

http://www.w3.org/2001/XMLSchema#string

Naomi Ohbayashi

http://www.w3.org/2001/XMLSchema#string

Sumiko Gomi

http://www.w3.org/2001/XMLSchema#string

Takaho Terada

http://www.w3.org/2001/XMLSchema#string

Takako Fujimoto

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Tomokazu Matsusue

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P2860

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

Diversity of the pyruvate dehydrogenase kinase gene family in humans

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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763-73

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scholarly article

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10.1107/S090744491102405X

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Pt 9

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67

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Mikako Shirouzu

Shigeyuki Yokoyama

Mutsuko Kukimoto-Niino

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2011-09-01T00:00:00Z

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21904029

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