NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
about
Interplay between human DNA repair proteins at a unique double-strand break in vivoThe phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repressionSIRT1 regulates the function of the Nijmegen breakage syndrome proteinA supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damagePhospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damageVRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damageFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionMdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retentionRereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpointDNA end resection: many nucleases make light workDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerFunctional Role of NBS1 in Radiation Damage Response and Translesion DNA SynthesisStructure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage SitesThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlMolecular mechanism of the recruitment of NBS1/hMRE11/hRAD50 complex to DNA double-strand breaks: NBS1 binds to gamma-H2AX through FHA/BRCT domainFertility defects revealing germline biallelic nonsense NBN mutationsAssembly of Slx4 signaling complexes behind DNA replication forksGammaH2AX and cancerHistone H2AX phosphorylation is dispensable for the initial recognition of DNA breaksAnalysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair.Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancerBisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation.Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responseWRN participates in translesion synthesis pathway through interaction with NBS1H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy.MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.DNA repair deficiency in neurodegeneration.DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.Nucleolin participates in DNA double-strand break-induced damage response through MDC1-dependent pathwayHCoDES reveals chromosomal DNA end structures with single-nucleotide resolutionNijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability.Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeastPhosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaksGenetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer.
P2860
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P2860
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@ast
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en-gb
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@nl
type
label
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@ast
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en-gb
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@nl
prefLabel
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@ast
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en-gb
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@nl
P2093
P1433
P1476
NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
@en
P2093
Asako Nakamura
Hiroshi Tauchi
Junya Kobayashi
Keiji Tanimoto
Ken-ichi Morishima
Kenshi Komatsu
Shuichi Sakamoto
Toshiko Kobayashi
P304
P356
10.1016/S0960-9822(02)01259-9
P407
P577
2002-10-01T00:00:00Z