Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint
about
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinIdas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progressionTwo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.And-1 is required for the stability of histone acetyltransferase Gcn5DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpointDisruption of mechanisms that prevent rereplication triggers a DNA damage responseGeminin regulates neuronal differentiation by antagonizing Brg1 activityThe chromosome cycle: coordinating replication and segregation. Second in the cycles review series.Regulation of replication licensing by acetyltransferase Hbo1.Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant.Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damagePrevention of DNA re-replication in eukaryotic cellsDifferentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activityReplication licensing and cancer--a fatal entanglement?Selective killing of cancer cells by suppression of geminin activityClaspin promotes normal replication fork rates in human cellsPreventing re-replication of chromosomal DNA.Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replicationFunctional domains of the Xenopus replication licensing factor Cdt1Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extractsThe Non-Canonical Role of Aurora-A in DNA ReplicationGenomic instability in cancer.Re-replication of a centromere induces chromosomal instability and aneuploidyThe Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication LicensingReplication fork instability and the consequences of fork collisions from rereplicationCDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiationPCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitinationCellular checkpoint mechanisms monitoring proper initiation of DNA replicationIdentification of genes that are essential to restrict genome duplication to once per cell divisionAcidic nucleoplasmic DNA-binding protein (And-1) controls chromosome congression by regulating the assembly of centromere protein A (CENP-A) at centromeres.Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis.NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cellsCRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationAn ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.The APC/C inhibitor, Emi1, is essential for prevention of rereplicationAPC/C--the master controller of origin licensing?ATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/CReplication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.DDB1 maintains genome integrity through regulation of Cdt1
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P2860
Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@ast
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@en
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@nl
type
label
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@ast
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@en
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@nl
prefLabel
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@ast
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@en
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@nl
P2860
P3181
P1476
Rereplication by depletion of ...... nd activates a G2/M checkpoint
@en
P2093
Yuefeng Chen
P2860
P304
P3181
P356
10.1128/MCB.24.16.7140-7150.2004
P407
P577
2004-08-01T00:00:00Z