Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice - Test2 - elhamkhani - TriplyDB

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

http://www.wikidata.org/entity/Q24317631

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Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease Mouse Genetic Models of Human Brain Disorders The associations between Parkinson's disease and cancer: the plot thickens Current understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor design The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts Parkinson's disease and immune system: is the culprit LRRKing in the periphery?Dysregulation of autophagy and mitochondrial function in Parkinson's disease LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives Parkinson's disease: animal models and dopaminergic cell vulnerability Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents Role of LRRK2 kinase dysfunction in Parkinson disease Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication Short- and long-term effects of LRRK2 on axon and dendrite growth Bcl-xL is necessary for neurite outgrowth in hippocampal neurons Models for LRRK2-Linked Parkinsonism.Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology Nestin-positive/SOX2-negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice LRRK2: an éminence grise of Wnt-mediated neurogenesis?Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Parkinson's disease mouse models in translational research.

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

http://www.wikidata.org/entity/Q24317631

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年論文

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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type

label

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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prefLabel

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

@ast

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

@en

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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J.NBD.2010.12.008

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Neurobiology of Disease

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A T Braithwaite

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P2860

Cell therapy in Huntington disease

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Discovery of a proneurogenic, neuroprotective chemical

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

LRRK2 in Parkinson's disease: protein domains and functional insights

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706-16

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scholarly article

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2736878

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10.1016/J.NBD.2010.12.008

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3

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41

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49693211

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21168496

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regulation of branching morphogenesis of a nerve

regulation of neuroblast proliferation

Leucine rich repeat kinase 2

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3059106

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