Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins - Test2 - elhamkhani - TriplyDB

Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins

Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins

http://www.wikidata.org/entity/Q24337460

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Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase The role of posttranslational modifications in the assembly of stress granules Enzyme-substrate intermediate formation at lysine 329 of human deoxyhypusine synthase Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase Molecular evolution by change of function. Alkaloid-specific homospermidine synthase retained all properties of deoxyhypusine synthase except binding the eIF5A precursor protein A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex eIF5A promotes translation elongation, polysome disassembly and stress granule assembly Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.Functional significance of eIF5A and its hypusine modification in eukaryotes Deoxyhypusine synthase from tobacco. cDNA isolation, characterization, and bacterial expression of an enzyme with extended substrate specificity.Deoxyhypusine synthase generates and uses bound NADH in a transient hydride transfer mechanism.Cryptosporidium parvum has an active hypusine biosynthesis pathway.Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.Assay of deoxyhypusine synthase activity Assay of deoxyhypusine hydroxylase activity.Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologs Polyamines and their metabolites as diagnostic markers of human diseases.The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.Independent roles of eIF5A and polyamines in cell proliferation.Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.Cloning and expression of a cDNA encoding homospermidine synthase from Senecio vulgaris (Asteraceae) in Escherichia coli.Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA.Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA.

P2860

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P2860

Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins

http://www.wikidata.org/entity/Q24337460

description

1995 nî lūn-bûn

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1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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JBC.270.38.22386

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Journal of Biological Chemistry

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Cloning and expression of huma ...... ant enzyme and mutant proteins

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P2093

E C Wolff

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M H Park

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Y A Joe

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P2860

Identification of YHR068w in Saccharomyces cerevisiae chromosome VIII as a gene for deoxyhypusine synthase. Expression and characterization of the enzyme.

Deoxyhypusine synthase from rat testis: purification and characterization

Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries.

Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor.

Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D.

Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.

Is hypusine essential for eukaryotic cell proliferation?

Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation.

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.

Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.

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22386-92

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38

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270

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Deoxyhypusine synthase

protein biosynthesis

protein structure