Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.
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Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5AWhole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesiaPost-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modificationThe post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modificationeIF5A isoforms and cancer: two brothers for two functions?A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkDDeoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileutonA novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformationDrug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory TrialStructural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeatsGenome-wide association analysis for heat tolerance at flowering detected a large set of genes involved in adaptation to thermal and other stresses.Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.Functional significance of eIF5A and its hypusine modification in eukaryotesIron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.Suppression of exogenous gene expression by spermidine/spermine N1-acetyltransferase 1 (SSAT1) cotransfection.Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.Advances in iron chelation: an update.A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.The hypusine-containing translation factor eIF5A.Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).Genome-wide analyses and functional classification of proline repeat-rich proteins: potential role of eIF5A in eukaryotic evolutionDifferential expression of eIF5A-1 and eIF5A-2 in human cancer cells.The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.miR-331-3p regulates expression of neuropilin-2 in glioblastoma.Assay of deoxyhypusine hydroxylase activity.Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].Biological Relevance and Therapeutic Potential of the Hypusine Modification System.Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologsRegulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cellsThe translation factor eIF5A and human cancer.Proteome-scale analysis of biochemical activity.Elongation factor 3, EF3, associates with the calcium channel Cch1 and targets Cch1 to the plasma membrane in Cryptococcus neoformans.Posttranslational hypusination of the eukaryotic translation initiation factor-5A regulates Fusarium graminearum virulence
P2860
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P2860
Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Molecular cloning, expression, ...... epeat-containing metalloenzyme
@nl
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@ast
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en-gb
type
label
Molecular cloning, expression, ...... epeat-containing metalloenzyme
@nl
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@ast
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en-gb
prefLabel
Molecular cloning, expression, ...... epeat-containing metalloenzyme
@nl
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@ast
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en-gb
P2093
P2860
P3181
P356
P1476
Molecular cloning, expression, ...... peat-containing metalloenzyme.
@en
P2093
Edith C Wolff
Jong-Hwan Park
Jörn Kaevel
Myung Hee Park
Yeon Sook Kim
P2860
P3181
P356
10.1073/PNAS.0509348102
P407
P577
2005-12-21T00:00:00Z