Functional significance of eIF5A and its hypusine modification in eukaryotes - Test2 - elhamkhani - TriplyDB

Functional significance of eIF5A and its hypusine modification in eukaryotes

Functional significance of eIF5A and its hypusine modification in eukaryotes

http://www.wikidata.org/entity/Q33691772

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Post-translational modification by β-lysylation is required for activity of Escherichia coli elongation factor P (EF-P)Serine, glycine and one-carbon units: cancer metabolism in full circle eIF5A isoforms and cancer: two brothers for two functions?Metabolic reprogramming and metabolic dependency in T cells Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine Fertility and polarized cell growth depends on eIF5A for translation of polyproline-rich formins in Saccharomyces cerevisiae.Protein stability: a crystallographer's perspective Modulation of protein synthesis by polyamines Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a β-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.The role of eIF5A in epidermal growth factor-induced proliferation of corneal epithelial cell association with PI3-k/Akt activation.Characterization of a eukaryotic translation initiation factor 5A homolog from Tamarix androssowii involved in plant abiotic stress tolerance.Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences Special delivery: distributing iron in the cytosol of mammalian cells.SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH.Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells.Cryptosporidium parvum has an active hypusine biosynthesis pathway.Thermospermine is not a minor polyamine in the plant kingdom.Cofactor biosynthesis through protein post-translational modification.Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.The hypusine-containing translation factor eIF5A.A tumour suppressor network relying on the polyamine-hypusine axis.Biochemistry. Getting past polyproline pauses Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies Eukaryotic initiation factor 5A plays an essential role in luteinizing hormone receptor regulation The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.

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P2860

Functional significance of eIF5A and its hypusine modification in eukaryotes

http://www.wikidata.org/entity/Q33691772

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2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Functional significance of eIF5A and its hypusine modification in eukaryotes

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Functional significance of eIF5A and its hypusine modification in eukaryotes

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type

label

Functional significance of eIF5A and its hypusine modification in eukaryotes

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Functional significance of eIF5A and its hypusine modification in eukaryotes

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prefLabel

Functional significance of eIF5A and its hypusine modification in eukaryotes

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Functional significance of eIF5A and its hypusine modification in eukaryotes

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Functional significance of eIF5A and its hypusine modification in eukaryotes

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P2093

C F Zanelli

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K Nishimura

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M H Park

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S R Valentini

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P2860

Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression

Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.

Identification and characterization of eukaryotic initiation factor 5A-2

Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus

Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins

Crystal structure of elongation factor P from Thermus thermophilus HB8

Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification

The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification

Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2

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