MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
about
Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substratesRFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damageATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsMPS1-dependent mitotic BLM phosphorylation is important for chromosome stabilityMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2DNA mismatch repair: molecular mechanism, cancer, and ageingLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsImpact of DNA mismatch repair system alterations on human fertility and related treatmentsATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient backgroundStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesThe role of checkpoint kinase 1 in sensitivity to topoisomerase I poisonsN-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells.DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.Sex, Scavengers, and Chaperones: Transcriptome Secrets of Divergent Symbiodinium Thermal Tolerances.Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.The mismatch repair system modulates curcumin sensitivity through induction of DNA strand breaks and activation of G2-M checkpoint.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitroHuman pluripotent stem cells have a novel mismatch repair-dependent damage response.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sitesO6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair.Major differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylatorTethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell linesThe human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylaseSqualene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 PhosphataseThe human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylaseIdentification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.
P2860
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P2860
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@ast
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en-gb
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@nl
type
label
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@ast
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en-gb
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@nl
prefLabel
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@ast
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en-gb
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@nl
P2860
P921
P3181
P356
P1476
MSH2 and ATR form a signaling ...... ge response to DNA methylation
@en
P2860
P304
P3181
P356
10.1073/PNAS.2536810100
P407
P577
2003-12-23T00:00:00Z