Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.
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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentMIRO GTPases in Mitochondrial Transport, Homeostasis and PathologyQuantifying ubiquitin signalingPINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's diseasePhosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase ParkinActivation of the E3 ubiquitin ligase Parkin.Probes of ubiquitin E3 ligases enable systematic dissection of parkin activationStructural insights into Parkin substrate lysine targeting from minimal Miro substratesQuantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.Mitochondrial quality control: Easy come, easy goStructural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylationA Ubl/ubiquitin switch in the activation of ParkinOxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degenerationInteraction between RING1 (R1) and the Ubiquitin-like (UBL) Domains Is Critical for the Regulation of Parkin Activity.The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseMiro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.How mitochondrial dynamism orchestrates mitophagy.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Specificity and disease in the ubiquitin systemParkin and PINK1 functions in oxidative stress and neurodegeneration.Post translational modification of Parkin.Ubiquitin and Parkinson's disease through the looking glass of genetics.The Close Interconnection between Mitochondrial Dynamics and Mitophagy in Cancer.Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure.Twenty years since the discovery of the parkin gene.Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy.Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.Dual Function of Phosphoubiquitin in E3 Activation of Parkin.Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria.Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes.UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN.Parkinson's disease biomarker: a patent evaluation of WO2013153386.The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.Generation of phospho-ubiquitin variants by orthogonal translation reveals codon skipping.
P2860
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P2860
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Phosphorylation of Parkin at S ...... of Parkin E3 ligase activity.
@en
type
label
Phosphorylation of Parkin at S ...... of Parkin E3 ligase activity.
@en
prefLabel
Phosphorylation of Parkin at S ...... of Parkin E3 ligase activity.
@en
P2093
P2860
P356
P1433
P1476
Phosphorylation of Parkin at S ...... of Parkin E3 ligase activity.
@en
P2093
C James Hastie
Carla Baillie
Clare Johnson
Helen I Woodroof
Mark Peggie
Miratul M K Muqit
Patrick G A Pedrioli
Thomas Macartney
P2860
P304
P356
10.1098/RSOB.130213
P577
2014-03-19T00:00:00Z