WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate - Test2 - elhamkhani - TriplyDB

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

http://www.wikidata.org/entity/Q24530650

about

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40 The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.WNK1 kinase balances T cell adhesion versus migration in vivo Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.Zebrafish WNK lysine deficient protein kinase 1 (wnk1) affects angiogenesis associated with VEGF signaling.Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.WNK kinases influence TRPV4 channel function and localization.The WNKs: atypical protein kinases with pleiotropic actions.Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.Insulin resistance, obesity, hypertension, and renal sodium transport.LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Multigene kinase network, kidney transport, and salt in essential hypertension.Regulation of a third conserved phosphorylation site in SGK1 Hypertension: the missing WNKs.Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling.Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin.WNK signalling pathways in blood pressure regulation Downregulation of ACSM3 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.WNK Kinases in Development and Disease.Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migration.Functional specificity of Sgk1 and Akt1 on ENaC activity.The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.Dietary salt modulates the sodium chloride cotransporter expression likely through an aldosterone-mediated WNK4-ERK1/2 signaling pathway.PDK1-WNK1 signaling is affected by HBx and involved in the viability and metastasis of hepatic cells.Parallel comparative proteomics and phosphoproteomics reveal that cattle myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway.Thymosin β4 induces proliferation, invasion, and epithelial-to-mesenchymal transition of oral squamous cell carcinoma.WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.

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P2860

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

http://www.wikidata.org/entity/Q24530650

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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Biochemical Journal

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WNK1, the kinase mutated in an ...... rotein kinase B)/Akt substrate

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Alberto C Vitari

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Anne Phelan

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Barry J Collins

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Nick Morrice

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Sian Humphreys

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P2860

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

Mechanism of activation of protein kinase B by insulin and IGF-1

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

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257-68

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scholarly article

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4595418

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10.1042/BJ20031692

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P433

Pt 1

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P478

378

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P50

Alan R. Prescott

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2004-02-15T00:00:00Z

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14611643

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P932

1223938

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