about
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPaseInteraction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIKTTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and developmentNew roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesionThe Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateLoss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndromeActivated cAMP receptors switch encystation into sporulationA role for PP1/NIPP1 in steering migration of human cancer cellsMolecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferaseBslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicaseNuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutationCajal body proteins SMN and Coilin show differential dynamic behaviour in vivoRegulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylationAnalysis of the LKB1-STRAD-MO25 complexTmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjectsInhibition of autophagy in mitotic animal cellsKnockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataractThe specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability.mito-QC illuminates mitophagy and mitochondrial architecture in vivo.The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells.Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation.Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cellsHomeostasis in the vertebrate lens: mechanisms of solute exchange.Proof that Burkholderia strains form effective symbioses with legumes: a study of novel Mimosa-nodulating strains from South America.An intranucleolar body associated with rDNA.Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback.Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility.The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27YuaB functions synergistically with the exopolysaccharide and TasA amyloid fibers to allow biofilm formation by Bacillus subtilis.Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.Cellular responses to the metal-binding properties of metformin.Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stressDeficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Alan R Prescott
@nl
Alan R Prescott
@sl
Alan R. Prescott
@en
Alan R. Prescott
@es
type
label
Alan R Prescott
@nl
Alan R Prescott
@sl
Alan R. Prescott
@en
Alan R. Prescott
@es
prefLabel
Alan R Prescott
@nl
Alan R Prescott
@sl
Alan R. Prescott
@en
Alan R. Prescott
@es
P106
P1153
7005983965
P21
P31
P496
0000-0002-0747-7317