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Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivoInteraction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmIdentification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIKMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesTTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and developmentIdentification of Protor as a novel Rictor-binding component of mTOR complex-2New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesionLKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationThe WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transportersCrystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocketStructural insights into the recognition of substrates and activators by the OSR1 kinase14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localizationWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateA phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation.Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityFunctional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphateBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeCrystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptorInteractions of LY333531 and other bisindolyl maleimide inhibitors with PDK1Structure of the OSR1 kinase, a hypertension drug targetATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour SuppressorStructural basis for the recruitment of glycogen synthase by glycogeninMolecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoRegulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylationControl of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chainsIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinasesThe LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cellsSPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stressStandardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts.Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicityInhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Maria Deak
@ast
Maria Deak
@en
Maria Deak
@es
Maria Deak
@nl
Maria Deak
@sl
type
label
Maria Deak
@ast
Maria Deak
@en
Maria Deak
@es
Maria Deak
@nl
Maria Deak
@sl
prefLabel
Maria Deak
@ast
Maria Deak
@en
Maria Deak
@es
Maria Deak
@nl
Maria Deak
@sl