Critical role for a central part of Mdm2 in the ubiquitylation of p53.
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Turning the RING domain protein MdmX into an active ubiquitin-protein ligaseAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationTranscription factor TAFII250 promotes Mdm2-dependent turnover of p53MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityIFI16 as a negative regulator in the regulation of p53 and p21(Waf1)Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stressMDM2 and MDMX: Alone and together in regulation of p53Therapeutic considerations for Mdm2: not just a one trick ponyEngineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transferMDM2 oligomers: antagonizers of the guardian of the genome.MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.Autoactivation of the MDM2 E3 ligase by intramolecular interaction.Nucleolar stress with and without p53.Mechanism of p53 stabilization by ATM after DNA damage.The central region of HDM2 provides a second binding site for p53.Deconstructing nucleotide binding activity of the Mdm2 RING domain.HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication.A novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumorsHerp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycSignaling to p53: ribosomal proteins find their way.ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer.Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.Abnormal MDMX degradation in tumor cells due to ARF deficiencyMDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 functionThe Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.MDM2 is a novel E3 ligase for HIV-1 Vif.Functions of MDMX in the modulation of the p53-response.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
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P2860
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@en
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@nl
type
label
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@en
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@nl
prefLabel
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@en
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@nl
P2093
P2860
P1476
Critical role for a central part of Mdm2 in the ubiquitylation of p53.
@en
P2093
Aart G Jochemsen
Erik Meulmeester
Karen H Vousden
Robert Stad
Ruth Frenk
P2860
P304
P356
10.1128/MCB.23.14.4929-4938.2003
P407
P577
2003-07-01T00:00:00Z